ARAF - Serine/threonine-protein kinase A-Raf - human protein (Function)
 
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ARAF »  Serine/threonine-protein kinase A-Raf   [ EC 2.7.11.1 ]
 
Protein also known as:  Proto-oncogene A-Raf-1.
Gene name:  ARAF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 73 2
GENE REF ISO

Function

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Overview 
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Receptor signaling protein activitydefinition[GO:0005057] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032434]  
1
  • IMPUniProtKB
Regulation of TOR signalingdefinition[GO:0032006]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+369  
Bladder cancer  hsa05219+369  
Chronic myeloid leukemia  hsa05220+369  
Colorectal cancer  hsa05210+369  
Endometrial cancer  hsa05213+369  
ErbB signaling pathway  hsa04012+369  
Glioma  hsa05214+369  
Hepatitis C  hsa05160+369  
Insulin signaling pathway  hsa04910+369  
Long-term depression  hsa04730+369  
Long-term potentiation  hsa04720+369  
Melanoma  hsa05218+369  
Natural killer cell mediated cytotoxicity  hsa04650+369  
Pancreatic cancer  hsa05212+369  
Pathways in cancer  hsa05200+369  
Progesterone-mediated oocyte maturation  hsa04914+369  
Prostate cancer  hsa05215+369  
Regulation of actin cytoskeleton  hsa04810+369  
Renal cell carcinoma  hsa05211+369  
Vascular smooth muscle contraction  hsa04270+369  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ARAF
GenomeRNAi: 369
PRO: PR:P10398
Chemistry
GuidetoPHARMACOLOGY: 1933