BCL2 - Apoptosis regulator Bcl-2 - human protein (Function)
 
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BCL2 »  Apoptosis regulator Bcl-2
 
Gene name:  BCL2
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
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1 1227 2
GENE REF ISO

Function

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Overview 
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).  
2
  • UniProtKB
GO molecular function 
BH3 domain bindingdefinition[GO:0051434]  
1
  • UniProtKB
Channel activitydefinition[GO:0015267]  
1
  • BHF-UCL
Channel inhibitor activitydefinition[GO:0016248]  
1
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Protease bindingdefinition[GO:0002020]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
48
  • IntAct
  • UniProtKB
  • HGNC
  • ParkinsonsUK-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein phosphatase 2A bindingdefinition[GO:0051721] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • MGI
Transcription factor bindingdefinition[GO:0008134] silver  
1
  • Ortholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
2
  • MGI
Axon regenerationdefinition[GO:0031103] silver  
1
  • Ortholog Compara
Axonogenesisdefinition[GO:0007409] silver  
1
  • Ortholog Compara
B cell homeostasisdefinition[GO:0001782] silver  
1
  • Ortholog Compara
B cell lineage commitmentdefinition[GO:0002326] silver  
1
  • Ortholog Compara
B cell proliferationdefinition[GO:0042100]  
1
  • MGI
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • UniProtKB
Behavioral fear responsedefinition[GO:0001662] silver  
1
  • Ortholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
CD8-positive, alpha-beta T cell lineage commitmentdefinition[GO:0043375] silver  
1
  • Ortholog Compara
Cell agingdefinition[GO:0007569] silver  
1
  • Ortholog Compara
Cell growthdefinition[GO:0016049] silver  
1
  • Ortholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Cellular response to glucose starvationdefinition[GO:0042149] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to organic substancedefinition[GO:0071310] silver  
1
  • Ortholog Compara
Cochlear nucleus developmentdefinition[GO:0021747] silver  
1
  • Ortholog Compara
Defense response to virusdefinition[GO:0051607]  
1
  • UniProtKB
Developmental growthdefinition[GO:0048589] silver  
1
  • Ortholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
1
  • Ortholog Compara
Ear developmentdefinition[GO:0043583] silver  
1
  • Ortholog Compara
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
1
  • UniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • MGI
Female pregnancydefinition[GO:0007565]  
1
  • UniProtKB
Focal adhesion assemblydefinition[GO:0048041] silver  
1
  • Ortholog Compara
Gland morphogenesisdefinition[GO:0022612] silver  
1
  • Ortholog Compara
Glomerulus developmentdefinition[GO:0032835] silver  
1
  • Ortholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
1
  • Ortholog Compara
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
1
  • Ortholog Compara
Humoral immune responsedefinition[GO:0006959]  
1
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • RefGenome
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • MGI
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631] silver  
1
  • Ortholog Compara
Lymphoid progenitor cell differentiationdefinition[GO:0002320] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Melanin metabolic processdefinition[GO:0006582] silver  
1
  • Ortholog Compara
Melanocyte differentiationdefinition[GO:0030318] silver  
1
  • Ortholog Compara
Mesenchymal cell developmentdefinition[GO:0014031] silver  
1
  • Ortholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
1
  • Ortholog Compara
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
13
  • UniProtKB
  • MGI
  • ParkinsonsUK-UCL
  • BHF-UCL
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234]  
1
  • UniProtKB
Negative regulation of autophagydefinition[GO:0010507]  
1
  • UniProtKB
Negative regulation of calcium ion transport into cytosoldefinition[GO:0010523] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
1
  • Ortholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
1
  • Ortholog Compara
Negative regulation of cellular pH reductiondefinition[GO:0032848]  
1
  • UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • MGI
Negative regulation of G1/S transition of mitotic cell cycledefinition[GO:2000134] silver  
1
  • Ortholog Compara
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243]  
1
  • UniProtKB
Negative regulation of mitochondrial depolarizationdefinition[GO:0051902]  
1
  • UniProtKB
Negative regulation of myeloid cell apoptotic processdefinition[GO:0033033] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • MGI
Negative regulation of ossificationdefinition[GO:0030279] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689] silver  
1
  • Ortholog Compara
Negative regulation of retinal cell programmed cell deathdefinition[GO:0046671] silver  
1
  • Ortholog Compara
Neuron apoptotic processdefinition[GO:0051402]  
1
  • HGNC
Oocyte developmentdefinition[GO:0048599] silver  
1
  • Ortholog Compara
Organ growthdefinition[GO:0035265] silver  
1
  • Ortholog Compara
Ossificationdefinition[GO:0001503] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
1
  • Ortholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
1
  • Ortholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107] silver  
1
  • Ortholog Compara
Pigment granule organizationdefinition[GO:0048753] silver  
1
  • Ortholog Compara
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • UniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085] silver  
1
  • Ortholog Compara
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • MGI
Positive regulation of melanocyte differentiationdefinition[GO:0045636] silver  
1
  • Ortholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Positive regulation of neuron maturationdefinition[GO:0014042] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
1
  • Ortholog Compara
Positive regulation of skeletal muscle fiber developmentdefinition[GO:0048743] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
1
  • Ortholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Protein dephosphorylationdefinition[GO:0006470] silver  
1
  • Ortholog Compara
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • MGI
Reactive oxygen species metabolic processdefinition[GO:0072593] silver  
1
  • Ortholog Compara
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • MGI
Regulation of cell-matrix adhesiondefinition[GO:0001952] silver  
1
  • Ortholog Compara
Regulation of glycoprotein biosynthetic processdefinition[GO:0010559] silver  
1
  • Ortholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
1
  • HGNC
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • HGNC
Regulation of nitrogen utilizationdefinition[GO:0006808] silver  
1
  • Ortholog Compara
Regulation of protein heterodimerization activitydefinition[GO:0043497]  
1
  • UniProtKB
Regulation of protein homodimerization activitydefinition[GO:0043496]  
1
  • UniProtKB
Regulation of protein stabilitydefinition[GO:0031647] silver  
1
  • Ortholog Compara
Regulation of transmembrane transporter activitydefinition[GO:0022898]  
1
  • BHF-UCL
Regulation of viral genome replicationdefinition[GO:0045069] silver  
1
  • Ortholog Compara
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
2
  • HGNC
  • UniProtKB
Renal system processdefinition[GO:0003014] silver  
1
  • Ortholog Compara
Response to cytokinedefinition[GO:0034097]  
1
  • MGI
Response to drugdefinition[GO:0042493]  
2
  • UniProtKB
  • MGI
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to iron iondefinition[GO:0010039]  
1
  • UniProtKB
Response to ischemiadefinition[GO:0002931] silver  
1
  • Ortholog Compara
Response to nicotinedefinition[GO:0035094]  
1
  • UniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • UniProtKB
Response to toxic substancedefinition[GO:0009636]  
2
  • MGI
  • HGNC
Response to UV-Bdefinition[GO:0010224] silver  
1
  • Ortholog Compara
Spleen developmentdefinition[GO:0048536] silver  
1
  • Ortholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
1
  • Ortholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
1
  • Ortholog Compara
Thymus developmentdefinition[GO:0048538] silver  
1
  • Ortholog Compara
Transmembrane transportdefinition[GO:0055085]