BCL2 - Apoptosis regulator Bcl-2 - human protein (Function)
 
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BCL2 »  Apoptosis regulator Bcl-2
 
Gene name:  BCL2
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).  
1
  • CuratedUniProtKB
GO molecular function 
BH3 domain bindingdefinition[GO:0051434]  
1
  • IPIUniProtKB
Channel activitydefinition[GO:0015267]  
1
  • IDABHF-UCL
Channel inhibitor activitydefinition[GO:0016248]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protease bindingdefinition[GO:0002020]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
44
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein phosphatase 2A bindingdefinition[GO:0051721] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAMGI
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
  • IEAOrtholog Compara
Axon regenerationdefinition[GO:0031103] silver  
  • IEAOrtholog Compara
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
B cell homeostasisdefinition[GO:0001782] silver  
  • IEAOrtholog Compara
B cell lineage commitmentdefinition[GO:0002326] silver  
  • IEAOrtholog Compara
B cell proliferationdefinition[GO:0042100]  
1
  • IDAMGI
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • IMPUniProtKB
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
CD8-positive, alpha-beta T cell lineage commitmentdefinition[GO:0043375] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
2
  • IDAMGI
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IMPUniProtKB
Cellular response to glucose starvationdefinition[GO:0042149] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to organic substancedefinition[GO:0071310] silver  
  • IEAOrtholog Compara
Cochlear nucleus developmentdefinition[GO:0021747] silver  
  • IEAOrtholog Compara
Defense response to virusdefinition[GO:0051607]  
1
  • IDAUniProtKB
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Ear developmentdefinition[GO:0043583] silver  
  • IEAOrtholog Compara
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
1
  • TASUniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IDAMGI
Female pregnancydefinition[GO:0007565]  
1
  • NASUniProtKB
Focal adhesion assemblydefinition[GO:0048041] silver  
  • IEAOrtholog Compara
Gland morphogenesisdefinition[GO:0022612] silver  
  • IEAOrtholog Compara
Glomerulus developmentdefinition[GO:0032835] silver  
  • IEAOrtholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
  • IEAOrtholog Compara
Humoral immune responsedefinition[GO:0006959]  
1
  • TASUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IBARefGenome
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • IDAMGI
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631] silver  
  • IEAOrtholog Compara
Lymphoid progenitor cell differentiationdefinition[GO:0002320] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Melanin metabolic processdefinition[GO:0006582] silver  
  • IEAOrtholog Compara
Melanocyte differentiationdefinition[GO:0030318] silver  
  • IEAOrtholog Compara
Mesenchymal cell developmentdefinition[GO:0014031] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
12
  • IMPUniProtKB
  • IDAMGI
  • IDABHF-UCL
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234]  
1
  • IMPUniProtKB
Negative regulation of autophagydefinition[GO:0010507]  
1
  • TASUniProtKB
Negative regulation of calcium ion transport into cytosoldefinition[GO:0010523] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of cellular pH reductiondefinition[GO:0032848]  
1
  • IDAUniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IGIMGI
Negative regulation of G1/S transition of mitotic cell cycledefinition[GO:2000134] silver  
  • IEAOrtholog Compara
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243]  
1
  • IDAUniProtKB
Negative regulation of mitochondrial depolarizationdefinition[GO:0051902]  
1
  • TASUniProtKB
Negative regulation of mitotic cell cycledefinition[GO:0045930] silver  
  • IEAOrtholog Compara
Negative regulation of myeloid cell apoptotic processdefinition[GO:0033033] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • IDAMGI
Negative regulation of ossificationdefinition[GO:0030279] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689] silver  
  • IEAOrtholog Compara
Negative regulation of retinal cell programmed cell deathdefinition[GO:0046671] silver  
  • IEAOrtholog Compara
Neuron apoptotic processdefinition[GO:0051402]  
1
  • TASHGNC
Oocyte developmentdefinition[GO:0048599] silver  
  • IEAOrtholog Compara
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107] silver  
  • IEAOrtholog Compara
Pigment granule organizationdefinition[GO:0048753] silver  
  • IEAOrtholog Compara
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • IMPUniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085] silver  
  • IEAOrtholog Compara
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • IDAMGI
Positive regulation of melanocyte differentiationdefinition[GO:0045636] silver  
  • IEAOrtholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of neuron maturationdefinition[GO:0014042] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
  • IEAOrtholog Compara
Positive regulation of skeletal muscle fiber developmentdefinition[GO:0048743] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Protein dephosphorylationdefinition[GO:0006470] silver  
  • IEAOrtholog Compara
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • IDAMGI
Reactive oxygen species metabolic processdefinition[GO:0072593] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • IDAMGI
Regulation of cell-matrix adhesiondefinition[GO:0001952] silver  
  • IEAOrtholog Compara
Regulation of glycoprotein biosynthetic processdefinition[GO:0010559] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
1
  • ISSHGNC
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • ISSHGNC
Regulation of nitrogen utilizationdefinition[GO:0006808] silver  
  • IEAOrtholog Compara
Regulation of protein heterodimerization activitydefinition[GO:0043497]  
1
  • IDAUniProtKB
Regulation of protein homodimerization activitydefinition[GO:0043496]  
1
  • IDAUniProtKB
Regulation of protein stabilitydefinition[GO:0031647] silver  
  • IEAOrtholog Compara
Regulation of transmembrane transporter activitydefinition[GO:0022898]  
1
  • IDABHF-UCL
Regulation of viral genome replicationdefinition[GO:0045069] silver  
  • IEAOrtholog Compara
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
2
  • ISSHGNC
  • NASUniProtKB
Renal system processdefinition[GO:0003014] silver  
  • IEAOrtholog Compara
Response to aciddefinition[GO:0001101] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097]  
1
  • IDAMGI
Response to drugdefinition[GO:0042493]  
2
  • IMPUniProtKB
  • IDAMGI
Response to gamma radiationdefinition[GO:0010332] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039]  
1
  • IDAUniProtKB
Response to ischemiadefinition[GO:0002931] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094]  
1
  • IDAUniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • NASUniProtKB
Response to toxic substancedefinition[GO:0009636]  
2
  • IDAMGI
  • IDAHGNC
Response to UV-Bdefinition[GO:0010224] silver  
  • IEAOrtholog Compara
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+596  
Apoptosis  hsa04210+596  
Cholinergic synapse  hsa04725+596  
Colorectal cancer  hsa05210+596  
Focal adhesion  hsa04510+596  
Neurotrophin signaling pathway  hsa04722+596  
Pathways in cancer  hsa05200+596  
Prostate cancer  hsa05215+596  
Protein processing in endoplasmic reticulum  hsa04141+596  
Small cell lung cancer  hsa05222+596  
Toxoplasmosis  hsa05145+596  
Tuberculosis  hsa05152+596  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Bcl-2
GenomeRNAi: 596
PRO: PR:P10415