SPP1 - Osteopontin - human protein (Function)
 
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SPP1 »  Osteopontin
 
Protein also known as:  Secreted phosphoprotein 1 (SPP-1).
Gene name:  SPP1
Family name: Osteopontin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.  
  • CuratedUniProtKB
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Extracellular matrix bindingdefinition[GO:0050840] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Biomineral tissue developmentdefinition[GO:0031214]  
  • IEAUniProtKB KW
Cell adhesiondefinition[GO:0007155] silver  
  • IEAOrtholog Compara
Decidualizationdefinition[GO:0046697]  
1
  • TASBHF-UCL
Embryo implantationdefinition[GO:0007566]  
1
  • TASBHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Negative regulation of collateral sprouting of intact axon in response to injurydefinition[GO:0048685] silver  
  • IEAOrtholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of bone resorptiondefinition[GO:0045780] silver  
  • IEAOrtholog Compara
Positive regulation of cell-substrate adhesiondefinition[GO:0010811] silver  
  • IEAOrtholog Compara
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Response to vitamin Ddefinition[GO:0033280]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+6696  
Focal adhesion  hsa04510+6696  
Toll-like receptor signaling pathway  hsa04620+6696  
According to Reactome, this protein belongs to the following pathways:
Degradation of the extracellular matrix  REACT_118572  
Integrin cell surface interactions  REACT_13552  
Integrin cell surface interactions  REACT_216309  
Signaling by PDGF  REACT_16888  
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Cell adhesion  definition   [KW-0130]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Osteopontin
GenomeRNAi: 6696
PRO: PR:P10451