DLAT - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial - human protein (Function)
 
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DLAT »  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial   [ EC 2.3.1.12 ]
 
Protein also known as:  Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
Gene name:  DLAT
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.  
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  • UniProtKB
GO molecular function 
Dihydrolipoyllysine-residue acetyltransferase activitydefinition[GO:0004742]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
GO biological process 
Glucose metabolic processdefinition[GO:0006006]  
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  • UniProtKB KW
Tricarboxylic acid cycledefinition[GO:0006099]  
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  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.12: Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.  
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  • UniProtKB
It requires the following cofactor
 (R)-lipoate : Binds 2 lipoyl cofactors covalently.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+1737  
Glycolysis / Gluconeogenesis  hsa00010+1737  
Metabolic pathways  hsa01100+1737  
Pyruvate metabolism  hsa00620+1737  
According to Reactome, this protein belongs to the following pathways:
Pyruvate metabolism  REACT_2071  
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
Signaling by Retinoic Acid  REACT_267785  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links