TXN - Thioredoxin - human protein (Function)
 
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TXN »  Thioredoxin  (Trx)
 
Protein also known as:  Surface-associated sulphydryl protein (SASP).
Gene name:  TXN
Family name: Thioredoxin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.  
1
  • UniProtKB
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).  
1
  • UniProtKB
GO molecular function 
Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptordefinition[GO:0016671]  
1
  • RefGenome
Peptide disulfide oxidoreductase activitydefinition[GO:0015037] silver  
1
  • Ortholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • UniProtKB
Protein disulfide oxidoreductase activitydefinition[GO:0015035]  
1
  • RefGenome
GO biological process 
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • ParkinsonsUK-UCL
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cell redox homeostasisdefinition[GO:0045454]  
1
  • RefGenome
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Glycerol ether metabolic processdefinition[GO:0006662] silver  
1
  • InterPro 2 GO
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • PINC
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein export from nucleusdefinition[GO:0046826] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB
Positive regulation of DNA bindingdefinition[GO:0043388]  
1
  • UniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • ParkinsonsUK-UCL
Protein foldingdefinition[GO:0006457]  
1
  • RefGenome
Regulation of protein import into nucleus, translocationdefinition[GO:0033158]  
1
  • UniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Sulfate assimilationdefinition[GO:0000103]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathways:
Detoxification of Reactive Oxygen Species  REACT_264249  
Oxidative Stress Induced Senescence  REACT_169436  
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
The NLRP3 inflammasome  REACT_75808  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Transport  definition   [KW-0813]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Thioredoxin
GenomeRNAi: 7295
PRO: PR:P10599