TXN - Thioredoxin - human protein (Function)
 
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TXN »  Thioredoxin  (Trx)
 
Protein also known as:  Surface-associated sulphydryl protein (SASP).
Gene name:  TXN
Family name: Thioredoxin
Entry whose protein(s) existence is based on evidence at protein level
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1 194 2
GENE REF ISO

Function

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Overview 
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.  
5
  • CuratedUniProtKB
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).  
5
  • CuratedUniProtKB
GO molecular function 
Peptide disulfide oxidoreductase activitydefinition[GO:0015037] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Glycerol ether metabolic processdefinition[GO:0006662] silver  
  • IEAInterPro 2 GO
Negative regulation of protein export from nucleusdefinition[GO:0046826] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Positive regulation of DNA bindingdefinition[GO:0043388]  
1
  • IDAUniProtKB
Regulation of protein import into nucleus, translocationdefinition[GO:0033158]  
1
  • IDAUniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Detoxification of Reactive Oxygen Species  REACT_172715  
Oxidative Stress Induced Senescence  REACT_169436  
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
The NLRP3 inflammasome  REACT_75808  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Transport  definition   [KW-0813]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Thioredoxin
GenomeRNAi: 7295
PRO: PR:P10599