CTSA - Lysosomal protective protein - human protein (Function)
 
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CTSA »  Lysosomal protective protein   [ EC 3.4.16.5 ]
 
Protein also known as:  Protective protein for beta-galactosidase. Cleaved into:  Lysosomal protective protein 20 kDa chain; Lysosomal protective protein 32 kDa chain.
Gene name:  CTSA
Family name: Peptidase S10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.  
2
  • UniProtKB
GO molecular function 
Carboxypeptidase activitydefinition[GO:0004180]  
1
  • PINC
Enzyme activator activitydefinition[GO:0008047]  
1
  • PINC
Serine-type carboxypeptidase activitydefinition[GO:0004185]  
2
  • ParkinsonsUK-UCL
  • RefGenome
GO biological process 
Chaperone-mediated autophagydefinition[GO:0061684]  
1
  • ParkinsonsUK-UCL
Intracellular protein transportdefinition[GO:0006886]  
1
  • PINC
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • GOC
Proteolysisdefinition[GO:0006508]  
1
  • ParkinsonsUK-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • RefGenome
Regulation of chaperone-mediated autophagydefinition[GO:1904714]  
1
  • ParkinsonsUK-UCL
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • ParkinsonsUK-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.16.5: Release of a C-terminal amino acid with broad specificity.  
3
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+5476  
Renin-angiotensin system  hsa04614+5476  
According to Reactome, this protein belongs to the following pathways:
Glycosphingolipid metabolism  R-HSA-1660662  
MHC class II antigen presentation  R-HSA-2132295  
Sialic acid metabolism  R-HSA-4085001  
 

Keywords

Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P10619
Other
GeneWiki: Cathepsin_A
GenomeRNAi: 5476
PRO: PR:P10619
Protein family/group databases
ESTHER: human-CTSA [ Family name: Carboxypeptidase S10 ]
Chemistry
GuidetoPHARMACOLOGY: 1581