CYP2C8 - Cytochrome P450 2C8 - human protein (Function)
 
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CYP2C8 »  Cytochrome P450 2C8   [ EC 1.14.14.1 ]
 
Protein also known as:  S-mephenytoin 4-hydroxylase.
Gene name:  CYP2C8
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 2
GENE REF ISO

Function

 show evidences
Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).  
1
  • CuratedUniProtKB
GO molecular function 
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Caffeine oxidase activitydefinition[GO:0034875]  
1
  • IDABHF-UCL
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
1
  • IDABHF-UCL
GO biological process 
Drug metabolic processdefinition[GO:0017144]  
1
  • IDABHF-UCL
Exogenous drug catabolic processdefinition[GO:0042738]  
1
  • IDABHF-UCL
Organic acid metabolic processdefinition[GO:0006082]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDABHF-UCL
Oxidative demethylationdefinition[GO:0070989]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+1558  
Drug metabolism - cytochrome P450  hsa00982+1558  
Linoleic acid metabolism  hsa00591+1558  
Metabolic pathways  hsa01100+1558  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1558  
Retinol metabolism  hsa00830+1558  
According to Reactome, this protein belongs to the following pathways:
CYP2E1 reactions  REACT_13797  
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)  REACT_150134  
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)  REACT_150417  
Xenobiotics  REACT_13543  
Caution 
Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P10632
Other
GeneWiki: CYP2C8
GenomeRNAi: 1558
PRO: PR:P10632