CYP2D6 - Cytochrome P450 2D6 - human protein (Function)
 
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Protein
Gene
References

 
CYP2D6 »  Cytochrome P450 2D6   [ EC 1.14.14.1 ]
 
Protein also known as:  Debrisoquine 4-hydroxylase.
Gene name:  CYP2D6
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 314 2
GENE REF ISO

Function

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Overview 
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.  
1
  • CuratedUniProtKB
GO molecular function 
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Drug bindingdefinition[GO:0008144]  
1
  • IDABHF-UCL
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
2
  • IDABHF-UCL
Oxidoreductase activitydefinition[GO:0016491]  
3
  • IDABHF-UCL
GO biological process 
Alkaloid catabolic processdefinition[GO:0009822]  
1
  • IDABHF-UCL
Alkaloid metabolic processdefinition[GO:0009820]  
1
  • IDABHF-UCL
Coumarin metabolic processdefinition[GO:0009804]  
1
  • IDABHF-UCL
Drug catabolic processdefinition[GO:0042737]  
1
  • IDABHF-UCL
Drug metabolic processdefinition[GO:0017144]  
2
  • IDABHF-UCL
Heterocycle metabolic processdefinition[GO:0046483]  
2
  • IDABHF-UCL
Isoquinoline alkaloid metabolic processdefinition[GO:0033076]  
1
  • IDABHF-UCL
Monoterpenoid metabolic processdefinition[GO:0016098]  
1
  • IDABHF-UCL
Negative regulation of bindingdefinition[GO:0051100]  
1
  • IDABHF-UCL
Negative regulation of cellular organofluorine metabolic processdefinition[GO:0090350]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IDABHF-UCL
Oxidative demethylationdefinition[GO:0070989]  
2
  • IDABHF-UCL
Steroid metabolic processdefinition[GO:0008202]  
1
  • IMPBHF-UCL
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • TASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P10635
Other
GeneWiki: CYP2D6
GenomeRNAi: 1565
PRO: PR:P10635