MAPT - Microtubule-associated protein tau - human protein (Function)
 
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MAPT »  Microtubule-associated protein tau
 
Protein also known as:  Neurofibrillary tangle protein.
Gene name:  MAPT
Entry whose protein(s) existence is based on evidence at protein level
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1 911 9
GENE REF ISO

Function

 show evidences
Overview 
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.  
1
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • IPIBHF-UCL
Enzyme bindingdefinition[GO:0019899]  
3
  • IPIUniProtKB
Lipoprotein particle bindingdefinition[GO:0071813]  
1
  • IPIUniProtKB
Microtubule bindingdefinition[GO:0008017]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
21
  • IPIIntAct
  • IPIAlzheimers_University_of_Toronto
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Axon cargo transportdefinition[GO:0008088] silver  
  • IEAOrtholog Compara
Axon extensiondefinition[GO:0048675] silver  
  • IEAOrtholog Compara
Generation of neuronsdefinition[GO:0048699]  
1
  • NASUniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • IDAUniProtKB
Mitochondrion transport along microtubuledefinition[GO:0047497] silver  
  • IEAOrtholog Compara
Negative regulation of intracellular transportdefinition[GO:0032387] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Positive regulation of axon extensiondefinition[GO:0045773]  
1
  • IDAUniProtKB
Positive regulation of microtubule polymerizationdefinition[GO:0031116]  
1
  • IDAUniProtKB
Regulation of autophagydefinition[GO:0010506]  
1
  • IGIMGI
Regulation of microtubule polymerizationdefinition[GO:0031113]  
1
  • NASUniProtKB
Regulation of microtubule-based movementdefinition[GO:0060632] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4137  
MAPK signaling pathway  hsa04010+4137  
According to Reactome, this protein belongs to the following pathway:
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Tau_protein
GenomeRNAi: 4137
PRO: PR:P10636