MAPT - Microtubule-associated protein tau - human protein (Function)
 
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Protein
Gene
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MAPT »  Microtubule-associated protein tau
 
Protein also known as:  Neurofibrillary tangle protein.
Gene name:  MAPT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.  
2
  • UniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • BHF-UCL
Enzyme bindingdefinition[GO:0019899]  
3
  • UniProtKB
Lipoprotein particle bindingdefinition[GO:0071813]  
1
  • UniProtKB
Microtubule bindingdefinition[GO:0008017]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
23
  • IntAct
  • Alzheimers_University_of_Toronto
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • PINC
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
1
  • Ortholog Compara
Axon cargo transportdefinition[GO:0008088] silver  
1
  • Ortholog Compara
Axon extensiondefinition[GO:0048675] silver  
1
  • Ortholog Compara
Generation of neuronsdefinition[GO:0048699]  
1
  • UniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • UniProtKB
Mitochondrion transport along microtubuledefinition[GO:0047497] silver  
1
  • Ortholog Compara
Negative regulation of intracellular transportdefinition[GO:0032387] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Positive regulation of axon extensiondefinition[GO:0045773]  
1
  • UniProtKB
Positive regulation of microtubule polymerizationdefinition[GO:0031116]  
2
  • CACAO
  • UniProtKB
Regulation of autophagydefinition[GO:0010506]  
1
  • MGI
Regulation of microtubule polymerizationdefinition[GO:0031113]  
1
  • UniProtKB
Regulation of microtubule-based movementdefinition[GO:0060632] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4137  
MAPK signaling pathway  hsa04010+4137  
According to Reactome, this protein belongs to the following pathway:
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Tau_protein
GenomeRNAi: 4137
PRO: PR:P10636