C7 - Complement component C7 - human protein (Function)
 
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Protein
Gene
References

 
C7 »  Complement component C7
 
Gene name:  C7
Family name: Complement C6/C7/C8/C9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.  
  • CuratedUniProtKB
GO biological process 
Cellular sodium ion homeostasisdefinition[GO:0006883] silver  
  • IEAOrtholog Compara
Complement activationdefinition[GO:0006956]  
1
  • TASPINC
Complement activation, alternative pathwaydefinition[GO:0006957]  
  • IEAUniProtKB KW
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Cytolysisdefinition[GO:0019835]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+730  
Prion diseases  hsa05020+730  
Systemic lupus erythematosus  hsa05322+730  
According to Reactome, this protein belongs to the following pathways:
Regulation of Complement cascade  REACT_118707  
Terminal pathway of complement  REACT_8028  
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Complement pathway  definition   [KW-0180]
Cytolysis  definition   [KW-0204]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 730
PRO: PR:P10643