PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - human protein (Function)
 
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PRKAR1A »  cAMP-dependent protein kinase type I-alpha regulatory subunit
 
Protein also known as:  Tissue-specific extinguisher 1 (TSE1). Cleaved into:  cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed.
Gene name:  PRKAR1A
Entry whose protein(s) existence is based on evidence at protein level
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1 136 2
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.  
2
  • CuratedUniProtKB
GO molecular function 
cAMP bindingdefinition[GO:0030552] silver  
  • IEAOrtholog Compara
cAMP-dependent protein kinase inhibitor activitydefinition[GO:0004862]  
1
  • IDABHF-UCL
cAMP-dependent protein kinase regulator activitydefinition[GO:0008603]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
Protein kinase A catalytic subunit bindingdefinition[GO:0034236]  
1
  • IPIBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IDAUniProtKB
GO biological process 
Cardiac muscle cell proliferationdefinition[GO:0060038] silver  
  • IEAOrtholog Compara
Female meiosisdefinition[GO:0007143] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Negative regulation of cAMP-dependent protein kinase activitydefinition[GO:2000480]  
1
  • IDABHF-UCL
Negative regulation of meiosisdefinition[GO:0045835] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Sarcomere organizationdefinition[GO:0045214] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+5573  
Insulin signaling pathway  hsa04910+5573  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5573
PRO: PR:P10644