CHGA - Chromogranin-A - human protein (Function)
 
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Protein
Gene
References

 
CHGA »  Chromogranin-A  (CgA)
 
Protein also known as:  Pituitary secretory protein I (SP-I). Cleaved into:  AL-11; Catestatin; EA-92; ER-37; ES-43; GE-25; GR-44; GV-19; LF-19; Pancreastatin; SS-18; Serpinin; Serpinin-RRG; Vasostatin-1; Vasostatin-2; WA-8; WE-14; p-Glu serpinin precursor.
Gene name:  CHGA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.  
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  • UniProtKB
Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed15723172 and PubMed24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed21214543). Acts as a potent scavenger of free radicals in vitro (PubMed24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed18541522).  
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  • UniProtKB
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.  
2
  • UniProtKB
GO biological process 
Defense response to fungusdefinition[GO:0050832]  
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  • UniProtKB KW
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • UniProtKB
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • UniProtKB
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB
Killing of cells of other organismdefinition[GO:0031640]  
1
  • UniProtKB KW
Mast cell activationdefinition[GO:0045576]  
1
  • UniProtKB
Mast cell chemotaxisdefinition[GO:0002551]  
1
  • UniProtKB
Mast cell cytokine productiondefinition[GO:0032762]  
1
  • UniProtKB
Mast cell degranulationdefinition[GO:0043303]  
1
  • UniProtKB
Negative regulation of catecholamine secretiondefinition[GO:0033604]  
1
  • UniProtKB
Positive regulation of dense core granule biogenesisdefinition[GO:2000707]  
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  • Ortholog Curator
Regulation of blood pressuredefinition[GO:0008217]  
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  • PINC
 

Keywords

Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Fungicide  definition   [KW-0295]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Chromogranin_A
GenomeRNAi: 1113
PRO: PR:P10645