ALPPL2 - Alkaline phosphatase, placental-like - human protein (Function)
 
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Gene
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ALPPL2 »  Alkaline phosphatase, placental-like   [ EC 3.1.3.1 ]
 
Protein also known as:  Placental alkaline phosphatase-like (PLAP-like).
Gene name:  ALPPL2
Family name: Alkaline phosphatase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Alkaline phosphatase activitydefinition[GO:0004035]  
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  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
GO biological process 
Dephosphorylationdefinition[GO:0016311]  
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  • GOC
  • EC 2 GO
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.1: A phosphate monoester + H(2)O an alcohol + phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
It requires the following cofactors
 Mg(2+) : Binds 1 Mg(2+) ion.  
1
  • UniProtKB
 Zn(2+) : Binds 2 Zn(2+) ions.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+251  
Metabolic pathways  hsa01100+251  
Note 
In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).  
1
  • UniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 251
PRO: PR:P10696