PF4V1 - Platelet factor 4 variant - human protein (Function)
 
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PF4V1 »  Platelet factor 4 variant
 
Protein also known as:  C-X-C motif chemokine 4 variant. Cleaved into:  Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74).
Gene name:  PF4V1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).  
2
  • UniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
1
  • RefGenome
CXCR chemokine receptor bindingdefinition[GO:0045236]  
1
  • RefGenome
Heparin bindingdefinition[GO:0008201]  
1
  • RefGenome
GO biological process 
Cell chemotaxisdefinition[GO:0060326]  
2
  • RefGenome
  • InterPro 2 GO
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • RefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • RefGenome
Immune responsedefinition[GO:0006955]  
1
  • RefGenome
Inflammatory responsedefinition[GO:0006954]  
1
  • RefGenome
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • RefGenome
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+5197  
Cytokine-cytokine receptor interaction  hsa04060+5197  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Common Pathway  REACT_1439  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5197
PRO: PR:P10720