KIT - Mast/stem cell growth factor receptor Kit - human protein (Function)
 
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KIT »  Mast/stem cell growth factor receptor Kit   [ EC 2.7.10.1 ]  (SCFR)
 
Protein also known as:  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117.
Gene name:  KIT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.  
10
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cytokine bindingdefinition[GO:0019955]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protease bindingdefinition[GO:0002020] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • TASPINC
Receptor signaling protein tyrosine kinase activitydefinition[GO:0004716] silver  
  • IEAInterPro 2 GO
Stem cell factor receptor activitydefinition[GO:0005020] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • IDAUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IDAUniProtKB
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDAUniProtKB
Cell chemotaxisdefinition[GO:0060326]  
1
  • IDAUniProtKB
Cellular response to thyroid hormone stimulusdefinition[GO:0097067] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDAUniProtKB
Dendritic cell cytokine productiondefinition[GO:0002371]  
  • ISSOrtholog Curator
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910]  
  • ISSOrtholog Curator
Digestive tract developmentdefinition[GO:0048565]  
  • ISSOrtholog Curator
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
  • IEAOrtholog Compara
Embryonic hemopoiesisdefinition[GO:0035162]  
  • ISSOrtholog Curator
Epithelial cell proliferationdefinition[GO:0050673] silver  
  • IEAOrtholog Compara
Erythrocyte differentiationdefinition[GO:0030218]  
  • ISSOrtholog Curator
Erythropoietin-mediated signaling pathwaydefinition[GO:0038162]  
  • ISSOrtholog Curator
Fc receptor signaling pathwaydefinition[GO:0038093]  
1
  • IDAUniProtKB
Germ cell migrationdefinition[GO:0008354] silver  
  • IEAOrtholog Compara
Glycosphingolipid metabolic processdefinition[GO:0006687] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097]  
1
  • TASUniProtKB
Immature B cell differentiationdefinition[GO:0002327]  
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Kit signaling pathwaydefinition[GO:0038109]  
1
  • IDAUniProtKB
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Lymphoid progenitor cell differentiationdefinition[GO:0002320] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • IEPUniProtKB
Mast cell chemotaxisdefinition[GO:0002551]  
1
  • IDAUniProtKB
Mast cell cytokine productiondefinition[GO:0032762]  
1
  • IDAUniProtKB
Mast cell degranulationdefinition[GO:0043303]  
1
  • IMPUniProtKB
Mast cell differentiationdefinition[GO:0060374]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Mast cell proliferationdefinition[GO:0070662]  
1
  • TASUniProtKB
Megakaryocyte developmentdefinition[GO:0035855]  
  • ISSOrtholog Curator
Melanocyte adhesiondefinition[GO:0097326]  
  • ISSOrtholog Curator
Melanocyte differentiationdefinition[GO:0030318]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Melanocyte migrationdefinition[GO:0097324]  
  • ISSOrtholog Curator
Myeloid progenitor cell differentiationdefinition[GO:0002318] silver  
  • IEAOrtholog Compara
Negative regulation of programmed cell deathdefinition[GO:0043069] silver  
  • IEAOrtholog Compara
Ovarian follicle developmentdefinition[GO:0001541]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAUniProtKB
Pigmentationdefinition[GO:0043473]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
1
  • IMPUniProtKB
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IMPUniProtKB
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • TASUniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • TASUniProtKB
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • TASUniProtKB
Positive regulation of pseudopodium assemblydefinition[GO:0031274] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IMPUniProtKB
Positive regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042511]  
1
  • IMPUniProtKB
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IMPUniProtKB
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
2
  • TASUniProtKB
Regulation of cell shapedefinition[GO:0008360]  
  • ISSOrtholog Curator
Regulation of developmental pigmentationdefinition[GO:0048070] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Signal transduction by phosphorylationdefinition[GO:0023014]  
1
  • TASGOC
Somatic stem cell divisiondefinition[GO:0048103] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Spermatid developmentdefinition[GO:0007286] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Stem cell differentiationdefinition[GO:0048863]  
  • ISSOrtholog Curator
Stem cell maintenancedefinition[GO:0019827]  
1
  • TASUniProtKB
T cell differentiationdefinition[GO:0030217]  
  • ISSOrtholog Curator
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
4
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues. Inhibited by imatinib/STI-571 (Gleevec) and sunitinib; these compounds maintain the kinase in an inactive conformation.  
5
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3815  
Cytokine-cytokine receptor interaction  hsa04060+3815  
Endocytosis  hsa04144+3815  
Hematopoietic cell lineage  hsa04640+3815  
Melanogenesis  hsa04916+3815  
Pathways in cancer  hsa05200+3815  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
Note 
Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CD117
GenomeRNAi: 3815
PRO: PR:P10721
Chemistry
GuidetoPHARMACOLOGY: 1805