CD28 - T-cell-specific surface glycoprotein CD28 - human protein (Function)
 
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CD28 »  T-cell-specific surface glycoprotein CD28
 
Protein also known as:  TP44; CD antigen CD28.
Gene name:  CD28
Entry whose protein(s) existence is based on evidence at protein level
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1 179 7
GENE REF ISO

Function

 show evidences
Overview 
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.  
  • CuratedUniProtKB
GO molecular function 
Coreceptor activitydefinition[GO:0015026]  
1
  • TASUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • NASUniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
10
  • IPIUniProtKB
  • IPIIntAct
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASUniProtKB
Cytokine biosynthetic processdefinition[GO:0042089]  
1
  • TASUniProtKB
Humoral immune responsedefinition[GO:0006959]  
1
  • TASUniProtKB
Negative thymic T cell selectiondefinition[GO:0045060] silver  
  • IEAOrtholog Compara
Positive regulation of alpha-beta T cell proliferationdefinition[GO:0046641] silver  
  • IEAOrtholog Compara
Positive regulation of inflammatory response to antigenic stimulusdefinition[GO:0002863] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of isotype switching to IgG isotypesdefinition[GO:0048304] silver  
  • IEAOrtholog Compara
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • IDAGOC
Positive regulation of T cell proliferationdefinition[GO:0042102]  
2
  • TASUniProtKB
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of translationdefinition[GO:0045727]  
1
  • NASUniProtKB
Positive regulation of viral genome replicationdefinition[GO:0045070]  
1
  • NASUniProtKB
Regulatory T cell differentiationdefinition[GO:0045066]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+940  
Autoimmune thyroid disease  hsa05320+940  
Cell adhesion molecules (CAMs)  hsa04514+940  
Graft-versus-host disease  hsa05332+940  
Intestinal immune network for IgA production  hsa04672+940  
Measles  hsa05162+940  
Rheumatoid arthritis  hsa05323+940  
Systemic lupus erythematosus  hsa05322+940  
T cell receptor signaling pathway  hsa04660+940  
Type I diabetes mellitus  hsa04940+940  
Viral myocarditis  hsa05416+940  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD28
GenomeRNAi: 940
PRO: PR:P10747