THRA - Thyroid hormone receptor alpha - human protein (Function)
 
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Protein
Gene
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THRA »  Thyroid hormone receptor alpha
 
Protein also known as:  Nuclear receptor subfamily 1 group A member 1.
Gene name:  THRA
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 95 4
GENE REF ISO

Function

 show evidences
Overview 
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.  
5
  • UniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490] silver  
1
  • Ortholog Compara
Intronic transcription regulatory region DNA bindingdefinition[GO:0044213] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • Ortholog Compara
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Steroid receptor RNA activator RNA bindingdefinition[GO:0002153] silver  
1
  • Ortholog Compara
TBP-class protein bindingdefinition[GO:0017025]  
1
  • UniProtKB
Thyroid hormone bindingdefinition[GO:0070324]  
3
  • UniProtKB
  • MGI
Thyroid hormone receptor activitydefinition[GO:0004887]  
3
  • BHF-UCL
  • UniProtKB
Transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingdefinition[GO:0003705] silver  
1
  • Ortholog Compara
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
3
  • BHF-UCL
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cartilage condensationdefinition[GO:0001502] silver  
1
  • Ortholog Compara
Cytoplasmic sequestering of transcription factordefinition[GO:0042994] silver  
1
  • Ortholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
1
  • Ortholog Compara
Embryonic organ developmentdefinition[GO:0048568] silver  
1
  • Ortholog Compara
Erythrocyte differentiationdefinition[GO:0030218] silver  
1
  • Ortholog Compara
Female courtship behaviordefinition[GO:0008050] silver  
1
  • Ortholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • BHF-UCL
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
5
  • GOC
  • InterPro 2 GO
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Learning or memorydefinition[GO:0007611] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Negative regulation of DNA-templated transcription, initiationdefinition[GO:2000143]  
1
  • UniProtKB
Negative regulation of RNA polymerase II transcriptional preinitiation complex assemblydefinition[GO:0017055]  
1
  • UniProtKB
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Ossificationdefinition[GO:0001503] silver  
1
  • Ortholog Compara
Positive regulation of female receptivitydefinition[GO:0045925] silver  
1
  • Ortholog Compara
Positive regulation of myotube differentiationdefinition[GO:0010831] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of heart contractiondefinition[GO:0008016] silver  
1
  • Ortholog Compara
Regulation of lipid catabolic processdefinition[GO:0050994] silver  
1
  • Ortholog Compara
Regulation of myeloid cell apoptotic processdefinition[GO:0033032] silver  
1
  • Ortholog Compara
Regulation of thyroid hormone mediated signaling pathwaydefinition[GO:0002155] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • BHF-UCL
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
1
  • Ortholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Thyroid gland developmentdefinition[GO:0030878] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • UniProtKB
Type I pneumocyte differentiationdefinition[GO:0060509] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+7067  
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  R-HSA-383280  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Thyroid_hormone_receptor_alpha
GenomeRNAi: 7067
PRO: PR:P10827
Chemistry
GuidetoPHARMACOLOGY: 588