GHR - Growth hormone receptor - human protein (Function)
 
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GHR »  Growth hormone receptor  (GH receptor)
 
Protein also known as:  Somatotropin receptor. Cleaved into:  Growth hormone-binding protein.
Gene name:  GHR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).  
  • CuratedUniProtKB
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.  
  • CuratedUniProtKB
Isoform  Iso 2   Up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.  
  • CuratedUniProtKB
GO molecular function 
Isoforms  Iso 1 and Iso 2   Growth factor bindingdefinition[GO:0019838]  
1
  • IPIBHF-UCL
Growth hormone receptor activitydefinition[GO:0004903] silver  
  • IEAOrtholog Compara
Peptide hormone bindingdefinition[GO:0017046]  
2
  • IPIBHF-UCL
Proline-rich region bindingdefinition[GO:0070064]  
1
  • ISSBHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IDABHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
  • ISSOrtholog Curator
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
SH2 domain bindingdefinition[GO:0042169] silver  
  • IEAOrtholog Compara
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103]  
  • ISSOrtholog Curator
Activation of JAK2 kinase activitydefinition[GO:0042977]  
  • ISSOrtholog Curator
Activation of MAPK activitydefinition[GO:0000187]  
  • ISSOrtholog Curator
Allantoin metabolic processdefinition[GO:0000255]  
  • ISSOrtholog Curator
Cartilage development involved in endochondral bone morphogenesisdefinition[GO:0060351] silver  
  • IEAOrtholog Compara
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IMPBHF-UCL
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
Citrate metabolic processdefinition[GO:0006101]  
  • ISSOrtholog Curator
Creatine metabolic processdefinition[GO:0006600]  
  • ISSOrtholog Curator
Creatinine metabolic processdefinition[GO:0046449]  
  • ISSOrtholog Curator
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Fatty acid metabolic processdefinition[GO:0006631]  
  • ISSOrtholog Curator
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
1
  • IMPBHF-UCL
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
  • IEAOrtholog Compara
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
1
  • IMPBHF-UCL
Isoleucine metabolic processdefinition[GO:0006549]  
  • ISSOrtholog Curator
JAK-STAT cascadedefinition[GO:0007259]  
  • ISSOrtholog Curator
Multicellular organismal metabolic processdefinition[GO:0044236]  
1
  • IMPBHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Oxaloacetate metabolic processdefinition[GO:0006107]  
  • ISSOrtholog Curator
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
  • IEAOrtholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018]  
1
  • IMPBHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
  • ISSOrtholog Curator
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • ISSBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • ISSBHF-UCL
Isoform  Iso 1 but not isoform  Iso 2   Receptor internalizationdefinition[GO:0031623]  
1
  • IDABHF-UCL
Regulation of multicellular organism growthdefinition[GO:0040014]  
  • ISSOrtholog Curator
Isoform  Iso 1 but not isoform  Iso 2   Response to cycloheximidedefinition[GO:0046898]  
1
  • IDABHF-UCL
Isoform  Iso 1   Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Response to fooddefinition[GO:0032094] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to interleukin-1definition[GO:0070555] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Succinate metabolic processdefinition[GO:0006105]  
  • ISSOrtholog Curator
Taurine metabolic processdefinition[GO:0019530]  
  • ISSOrtholog Curator
Valine metabolic processdefinition[GO:0006573]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+2690  
Jak-STAT signaling pathway  hsa04630+2690  
Neuroactive ligand-receptor interaction  hsa04080+2690  
According to Reactome, this protein belongs to the following pathways:
Growth hormone receptor signaling  REACT_111133  
Prolactin receptor signaling  REACT_115697  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Growth_hormone_receptor
GenomeRNAi: 2690
PRO: PR:P10912
Chemistry
GuidetoPHARMACOLOGY: 1720