MYL2 - Myosin regulatory light chain 2, ventricular/cardiac muscle isoform - human protein (Function)
 
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MYL2 »  Myosin regulatory light chain 2, ventricular/cardiac muscle isoform  (MLC-2)
 
Protein also known as:  Myosin light chain 2, slow skeletal/ventricular muscle isoform (MLC-2s/v).
Gene name:  MYL2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).  
3
  • UniProtKB
GO molecular function 
Actin monomer bindingdefinition[GO:0003785]  
1
  • BHF-UCL
Calcium ion bindingdefinition[GO:0005509]  
1
  • MGI
Myosin heavy chain bindingdefinition[GO:0032036]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Structural constituent of muscledefinition[GO:0008307]  
1
  • BHF-UCL
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048] silver  
1
  • Ortholog Compara
Cardiac myofibril assemblydefinition[GO:0055003]  
1
  • Ortholog Curator
Heart contractiondefinition[GO:0060047]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507]  
1
  • Ortholog Curator
Muscle cell fate specificationdefinition[GO:0042694] silver  
1
  • Ortholog Compara
Muscle fiber developmentdefinition[GO:0048747] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • BHF-UCL
Positive regulation of the force of heart contractiondefinition[GO:0098735]  
1
  • Ortholog Curator
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Regulation of striated muscle contractiondefinition[GO:0006942]  
1
  • PINC
Regulation of the force of heart contractiondefinition[GO:0002026]  
1
  • Ortholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+4633  
Dilated cardiomyopathy  hsa05414+4633  
Focal adhesion  hsa04510+4633  
Hypertrophic cardiomyopathy (HCM)  hsa05410+4633  
Leukocyte transendothelial migration  hsa04670+4633  
Regulation of actin cytoskeleton  hsa04810+4633  
Tight junction  hsa04530+4633  
According to Reactome, this protein belongs to the following pathway:
Striated Muscle Contraction  R-HSA-390522  
 

Keywords

Molecular function 
Motor protein  definition   [KW-0505]
Muscle protein  definition   [KW-0514]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYL2
GenomeRNAi: 4633
PRO: PR:P10916