LIPC - Hepatic triacylglycerol lipase - human protein (Function)
 
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LIPC »  Hepatic triacylglycerol lipase   [ EC 3.1.1.3 ]  (HL)
 
Protein also known as:  Lipase member C.
Gene name:  LIPC
Family name: AB hydrolase » Lipase
Entry whose protein(s) existence is based on evidence at protein level
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1 136 1
GENE REF ISO

Function

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Overview 
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
  • ISSOrtholog Curator
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
  • ISSOrtholog Curator
Phospholipase activitydefinition[GO:0004620]  
1
  • TASBHF-UCL
Triglyceride lipase activitydefinition[GO:0004806]  
2
  • IDABHF-UCL
GO biological process 
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IMPBHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • TASBHF-UCL
Fatty acid biosynthetic processdefinition[GO:0006633]  
1
  • IDABHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • IMPBHF-UCL
Intermediate-density lipoprotein particle remodelingdefinition[GO:0034373]  
1
  • TASBHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • IMPBHF-UCL
Phosphatidylcholine catabolic processdefinition[GO:0034638]  
1
  • TASBHF-UCL
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • ICBHF-UCL
Triglyceride catabolic processdefinition[GO:0019433]  
3
  • IDABHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • IMPBHF-UCL
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.3: Triacylglycerol + H(2)O diacylglycerol + a carboxylate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+3990  
Metabolic pathways  hsa01100+3990  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Hepatic_lipase
GenomeRNAi: 3990
PRO: PR:P11150