EGR2 - E3 SUMO-protein ligase EGR2 - human protein (Function)
 
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Protein
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EGR2 »  E3 SUMO-protein ligase EGR2
 
Gene name:  EGR2
Entry whose protein(s) existence is based on evidence at protein level
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1 68 2
GENE REF ISO

Function

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Overview 
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.  
1
  • CuratedUniProtKB
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
  • ISSOrtholog Curator
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420]  
1
  • TASPINC
Brain segmentationdefinition[GO:0035284] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular response to cAMPdefinition[GO:0071320] silver  
  • IBARefGenome
Cellular response to gonadotropin stimulusdefinition[GO:0071371] silver  
  • IBARefGenome
Facial nerve structural organizationdefinition[GO:0021612] silver  
  • IEAOrtholog Compara
Fat cell differentiationdefinition[GO:0045444]  
  • ISSOrtholog Curator
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Motor neuron axon guidancedefinition[GO:0008045] silver  
  • IEAOrtholog Compara
Myelinationdefinition[GO:0042552] silver  
  • IBARefGenome
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IBARefGenome
Peripheral nervous system developmentdefinition[GO:0007422]  
1
  • TASPINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Protein export from nucleusdefinition[GO:0006611]  
  • ISSOrtholog Curator
Protein sumoylationdefinition[GO:0016925]  
  • IEAUniPathway
Regulation of neuronal synaptic plasticitydefinition[GO:0048168] silver  
  • IBARefGenome
Regulation of ossificationdefinition[GO:0030278] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Rhombomere 3 formationdefinition[GO:0021660] silver  
  • IEAOrtholog Compara
Rhombomere 5 formationdefinition[GO:0021666] silver  
  • IEAOrtholog Compara
Rhythmic behaviordefinition[GO:0007622] silver  
  • IEAOrtholog Compara
Schwann cell differentiationdefinition[GO:0014037] silver  
  • IEAOrtholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IBARefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • ISSOrtholog Curator
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathway:
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Activator  definition   [KW-0010]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EGR2
GenomeRNAi: 1959
PRO: PR:P11161