EGR2 - E3 SUMO-protein ligase EGR2 - human protein (Function)
 
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EGR2 »  E3 SUMO-protein ligase EGR2   [ EC 6.3.2.- ]
 
Protein also known as:  Early growth response protein 2 (EGR-2).
Gene name:  EGR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 71 2
GENE REF ISO

Function

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Overview 
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.  
2
  • UniProtKB
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • Ortholog Curator
HMG box domain bindingdefinition[GO:0071837] silver  
1
  • Ortholog Compara
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • Ortholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • Ortholog Curator
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420]  
1
  • PINC
Brain segmentationdefinition[GO:0035284] silver  
1
  • Ortholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
1
  • RefGenome
Cellular response to gonadotropin stimulusdefinition[GO:0071371]  
1
  • RefGenome
Facial nerve structural organizationdefinition[GO:0021612] silver  
1
  • Ortholog Compara
Fat cell differentiationdefinition[GO:0045444]  
1
  • Ortholog Curator
Learning or memorydefinition[GO:0007611] silver  
1
  • Ortholog Compara
Motor neuron axon guidancedefinition[GO:0008045] silver  
1
  • Ortholog Compara
Myelinationdefinition[GO:0042552]  
1
  • RefGenome
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • RefGenome
Peripheral nervous system developmentdefinition[GO:0007422]  
1
  • PINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Protein export from nucleusdefinition[GO:0006611]  
1
  • Ortholog Curator
Protein sumoylationdefinition[GO:0016925]  
1
  • UniPathway
Regulation of neuronal synaptic plasticitydefinition[GO:0048168]  
1
  • RefGenome
Regulation of ossificationdefinition[GO:0030278] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Rhombomere 3 formationdefinition[GO:0021660] silver  
1
  • Ortholog Compara
Rhombomere 5 formationdefinition[GO:0021666] silver  
1
  • Ortholog Compara
Rhythmic behaviordefinition[GO:0007622] silver  
1
  • Ortholog Compara
Schwann cell differentiationdefinition[GO:0014037] silver  
1
  • Ortholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914]  
1
  • RefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Curator
Pathways 
This protein is involved in the following pathway
Protein modification; protein sumoylation  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Activator  definition   [KW-0010]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EGR2
GenomeRNAi: 1959
PRO: PR:P11161