SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2 - human protein (Function)
 
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Protein
Gene
References

 
SLC2A2 »  Solute carrier family 2, facilitated glucose transporter member 2
 
Protein also known as:  Glucose transporter type 2, liver (GLUT-2).
Gene name:  SLC2A2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 2
GENE REF ISO

Function

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Overview 
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.1.29  
GO molecular function 
D-glucose transmembrane transporter activitydefinition[GO:0055056] silver  
1
  • Ortholog Compara
Dehydroascorbic acid transporter activitydefinition[GO:0033300] silver  
1
  • Ortholog Compara
Insulin receptor bindingdefinition[GO:0005158] silver  
1
  • Ortholog Compara
Sugar:proton symporter activitydefinition[GO:0005351]  
1
  • RefGenome
GO biological process 
Carbohydrate utilizationdefinition[GO:0009758] silver  
1
  • Ortholog Compara
Dehydroascorbic acid transportdefinition[GO:0070837] silver  
1
  • Ortholog Compara
Fructose transportdefinition[GO:0015755] silver  
1
  • Ortholog Compara
Glucose importdefinition[GO:0046323]  
1
  • RefGenome
Hexose transmembrane transportdefinition[GO:0035428]  
1
  • RefGenome
Proton transportdefinition[GO:0015992]  
1
  • RefGenome
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Carbohydrate digestion and absorption  hsa04973+6514  
Maturity onset diabetes of the young  hsa04950+6514  
Type II diabetes mellitus  hsa04930+6514  
According to Reactome, this protein belongs to the following pathways:
Facilitative Na+-independent glucose transporters  R-HSA-428790  
Glucose transport  R-HSA-70153  
Hexose transport  R-HSA-189200  
Regulation of gene expression in beta cells  R-HSA-210745  
Regulation of insulin secretion  R-HSA-422356  
 

Keywords

Biological process 
Sugar transport  definition   [KW-0762]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6514
PRO: PR:P11168
Chemistry
GuidetoPHARMACOLOGY: 876