SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2 - human protein (Function)
 
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Protein
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SLC2A2 »  Solute carrier family 2, facilitated glucose transporter member 2
 
Protein also known as:  Glucose transporter type 2, liver (GLUT-2).
Gene name:  SLC2A2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 2
GENE REF ISO

Function

 show evidences
Overview 
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.1.29  
GO molecular function 
D-glucose transmembrane transporter activitydefinition[GO:0055056] silver  
  • IEAOrtholog Compara
Dehydroascorbic acid transporter activitydefinition[GO:0033300] silver  
  • IEAOrtholog Compara
GO biological process 
Dehydroascorbic acid transportdefinition[GO:0070837] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Carbohydrate digestion and absorption  hsa04973+6514  
Maturity onset diabetes of the young  hsa04950+6514  
Type II diabetes mellitus  hsa04930+6514  
According to Reactome, this protein belongs to the following pathways:
Facilitative Na+-independent glucose transporters  REACT_19343  
Glucose transport  REACT_212  
Hexose transport  REACT_9441  
Regulation of gene expression in beta cells  REACT_13819  
Regulation of insulin secretion  REACT_18325  
 

Keywords

Biological process 
Sugar transport  definition   [KW-0762]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6514
PRO: PR:P11168
Chemistry
GuidetoPHARMACOLOGY: 876