UMPS - Uridine 5'-monophosphate synthase - human protein (Function)
 
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Protein
Gene
References

 
UMPS »  Uridine 5'-monophosphate synthase  (UMP synthase)
 
Gene name:  UMPS
Family names: In the N-terminal section Purine/pyrimidine phosphoribosyltransferase
In the C-terminal section OMP decarboxylase
Entry whose protein(s) existence is based on evidence at protein level
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1 60 4
GENE REF ISO

Function

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GO molecular function 
Orotate phosphoribosyltransferase activitydefinition[GO:0004588]  
2
  • IDAUniProtKB
Orotidine-5'-phosphate decarboxylase activitydefinition[GO:0004590]  
2
  • IDAUniProtKB
GO biological process 
'de novo' pyrimidine nucleobase biosynthetic processdefinition[GO:0006207] silver  
  • IEAInterPro 2 GO
'de novo' UMP biosynthetic processdefinition[GO:0044205]  
  • IEAUniPathway
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
UMP biosynthetic processdefinition[GO:0006222]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.2.10: Orotidine 5'-phosphate + diphosphate orotate + 5-phospho-alpha-D-ribose 1-diphosphate.  
  • CuratedUniProtKB
EC 4.1.1.23: Orotidine 5'-phosphate UMP + CO(2).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - other enzymes  hsa00983+7372  
Metabolic pathways  hsa01100+7372  
Pyrimidine metabolism  hsa00240+7372  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Pyrimidine biosynthesis  definition   [KW-0665]
Molecular function 
Decarboxylase  definition   [KW-0210]
Glycosyltransferase  definition   [KW-0328]
Lyase  definition   [KW-0456]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links