ITGAM - Integrin alpha-M - human protein (Function)
 
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ITGAM »  Integrin alpha-M
 
Protein also known as:  Cell surface glycoprotein MAC-1 subunit alpha; CD antigen CD11b.
Gene name:  ITGAM
Family name: Integrin alpha chain
Entry whose protein(s) existence is based on evidence at protein level
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1 190 2
GENE REF ISO

Function

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Overview 
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.  
  • CuratedUniProtKB
GO molecular function 
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIUniProtKB
Heparan sulfate proteoglycan bindingdefinition[GO:0043395] silver  
  • IEAOrtholog Compara
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Opsonin bindingdefinition[GO:0001846] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
GO biological process 
Activated T cell proliferationdefinition[GO:0050798] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cellular extravasationdefinition[GO:0045123] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
  • IEAUniProtKB KW
Leukocyte cell-cell adhesiondefinition[GO:0007159] silver  
  • IEAOrtholog Compara
Microglia developmentdefinition[GO:0014005] silver  
  • IEAOrtholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+3684  
Cell adhesion molecules (CAMs)  hsa04514+3684  
Hematopoietic cell lineage  hsa04640+3684  
Legionellosis  hsa05134+3684  
Leishmaniasis  hsa05140+3684  
Leukocyte transendothelial migration  hsa04670+3684  
Pertussis  hsa05133+3684  
Phagosome  hsa04145+3684  
Regulation of actin cytoskeleton  hsa04810+3684  
Staphylococcus aureus infection  hsa05150+3684  
Tuberculosis  hsa05152+3684  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Immune System  REACT_6900  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Integrin  definition   [KW-0401]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Integrin_alpha_M
GenomeRNAi: 3684
PRO: PR:P11215