MBL2 - Mannose-binding protein C - human protein (Function)
 
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MBL2 »  Mannose-binding protein C  (MBP-C)
 
Protein also known as:  Mannose-binding lectin.
Gene name:  MBL2
Entry whose protein(s) existence is based on evidence at protein level
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1 291 1
GENE REF ISO

Function

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Overview 
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.  
2
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • RefGenome
Calcium-dependent protein bindingdefinition[GO:0048306]  
2
  • UniProtKB
Mannose bindingdefinition[GO:0005537]  
3
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • BHF-UCL
Complement activation, classical pathwaydefinition[GO:0006958]  
1
  • UniProtKB KW
Complement activation, lectin pathwaydefinition[GO:0001867]  
2
  • MGI
  • UniProtKB
Defense response to bacteriumdefinition[GO:0042742]  
1
  • BHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • MGI
Innate immune responsedefinition[GO:0045087]  
1
  • BHF-UCL
Killing by host of symbiont cellsdefinition[GO:0051873] silver  
1
  • Ortholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130]  
1
  • MGI
Negative regulation of viral processdefinition[GO:0048525]  
1
  • BHF-UCL
Opsonizationdefinition[GO:0008228]  
1
  • BHF-UCL
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+4153  
Phagosome  hsa04145+4153  
Staphylococcus aureus infection  hsa05150+4153  
According to Reactome, this protein belongs to the following pathways:
Initial triggering of complement  REACT_8024  
Lectin pathway of complement activation  REACT_7964  
 

Keywords

Biological process 
Complement activation lectin pathway  definition   [KW-1018]
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Mannan-binding_lectin
GenomeRNAi: 4153
PRO: PR:P11226