MBL2 - Mannose-binding protein C - human protein (Function)
 
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MBL2 »  Mannose-binding protein C  (MBP-C)
 
Protein also known as:  Mannan-binding protein.
Gene name:  MBL2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium-dependent protein bindingdefinition[GO:0048306]  
2
  • IPIUniProtKB
Mannose bindingdefinition[GO:0005537]  
2
  • NASUniProtKB
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASBHF-UCL
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Complement activation, lectin pathwaydefinition[GO:0001867]  
2
  • IDAMGI
  • IPIUniProtKB
Defense response to bacteriumdefinition[GO:0042742]  
1
  • TASBHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • IDAMGI
Killing by host of symbiont cellsdefinition[GO:0051873] silver  
  • IEAOrtholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130]  
1
  • IDAMGI
Opsonizationdefinition[GO:0008228]  
1
  • TASBHF-UCL
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+4153  
Phagosome  hsa04145+4153  
Staphylococcus aureus infection  hsa05150+4153  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement activation lectin pathway  definition   [KW-1018]
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Mannan-binding_lectin
GenomeRNAi: 4153
PRO: PR:P11226