CHRM1 - Muscarinic acetylcholine receptor M1 - human protein (Function)
 
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CHRM1 »  Muscarinic acetylcholine receptor M1
 
Gene name:  CHRM1
Entry whose protein(s) existence is based on evidence at protein level
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1 79 2
GENE REF ISO

Function

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Overview 
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.  
1
  • UniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
G-protein coupled acetylcholine receptor activitydefinition[GO:0016907] silver  
1
  • Ortholog Compara
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • PINC
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cellular protein modification processdefinition[GO:0006464]  
1
  • PINC
Cognitiondefinition[GO:0050890] silver  
1
  • InterPro 2 GO
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
1
  • PINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Neuromuscular synaptic transmissiondefinition[GO:0007274] silver  
1
  • Ortholog Compara
Phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007207]  
1
  • PINC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Positive regulation of intracellular protein transportdefinition[GO:0090316] silver  
1
  • Ortholog Compara
Positive regulation of ion transportdefinition[GO:0043270]  
1
  • MGI
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
1
  • PINC
Regulation of locomotiondefinition[GO:0040012] silver  
1
  • Ortholog Compara
Saliva secretiondefinition[GO:0046541] silver  
1
  • InterPro 2 GO
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1128  
Cholinergic synapse  hsa04725+1128  
Neuroactive ligand-receptor interaction  hsa04080+1128  
Regulation of actin cytoskeleton  hsa04810+1128  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Muscarinic acetylcholine receptors  REACT_16943  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Muscarinic_acetylcholine_receptor_M1
GenomeRNAi: 1128
PRO: PR:P11229
Chemistry
GuidetoPHARMACOLOGY: 13