CHRNB1 - Acetylcholine receptor subunit beta - human protein (Function)
 
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Protein
Gene
References

 
CHRNB1 »  Acetylcholine receptor subunit beta
 
Gene name:  CHRNB1
Entry whose protein(s) existence is based on evidence at protein level
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1 18 1
GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.1  
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
  • ISSOrtholog Curator
Contributes to acetylcholine receptor activitydefinition[GO:0015464]  
2
  • IMPUniProtKB
Contributes to acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
  • ISSOrtholog Curator
Channel activitydefinition[GO:0015267]  
1
  • IMPUniProtKB
Ligand-gated ion channel activitydefinition[GO:0015276]  
  • ISSOrtholog Curator
GO biological process 
Behavioral response to nicotinedefinition[GO:0035095]  
1
  • IMPUniProtKB
Cation transportdefinition[GO:0006812]  
1
  • IMPUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
  • IEAInterPro 2 GO
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Muscle contractiondefinition[GO:0006936]  
1
  • IMPUniProtKB
Muscle fiber developmentdefinition[GO:0048747]  
1
  • IMPUniProtKB
Neurological system processdefinition[GO:0050877]  
1
  • IMPUniProtKB
Neuromuscular synaptic transmissiondefinition[GO:0007274]  
1
  • IMPUniProtKB
Postsynaptic membrane organizationdefinition[GO:0001941]  
1
  • IMPUniProtKB
Regulation of membrane potentialdefinition[GO:0042391]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IMPUniProtKB
Synaptic transmission, cholinergicdefinition[GO:0007271]  
1
  • IMPUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • IMPGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1140  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNB1
GenomeRNAi: 1140
PRO: PR:P11230
Chemistry
GuidetoPHARMACOLOGY: 471