NAT2 - Arylamine N-acetyltransferase 2 - human protein (Function)
 
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Protein
Gene
References

 
NAT2 »  Arylamine N-acetyltransferase 2
 
Gene name:  NAT2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.  
  • CuratedUniProtKB
GO molecular function 
Arylamine N-acetyltransferase activitydefinition[GO:0004060]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.5: Acetyl-CoA + an arylamine CoA + an N-acetylarylamine.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Caffeine metabolism  hsa00232+10  
Drug metabolism - other enzymes  hsa00983+10  
Metabolic pathways  hsa01100+10  
According to Reactome, this protein belongs to the following pathway:
Acetylation  REACT_6732  
 

Keywords

Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: N-acetyltransferase_2
GenomeRNAi: 10
PRO: PR:P11245