BCR - Breakpoint cluster region protein - human protein (Function)
 
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BCR »  Breakpoint cluster region protein   [ EC 2.7.11.1 ]
 
Protein also known as:  Renal carcinoma antigen NY-REN-26.
Gene name:  BCR
Entry whose protein(s) existence is based on evidence at protein level
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1 254 2
GENE REF ISO

Function

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Overview 
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
GTPase activator activitydefinition[GO:0005096]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Rac GTPase activator activitydefinition[GO:0030675] silver  
  • IEAOrtholog Compara
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of neutrophil degranulationdefinition[GO:0043314] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chronic myeloid leukemia  hsa05220+613  
Pathways in cancer  hsa05200+613  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Guanine-nucleotide releasing factor  definition   [KW-0344]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCR_(gene)
GenomeRNAi: 613
PRO: PR:P11274