BCR - Breakpoint cluster region protein - human protein (Medical)
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View

BCR »  Breakpoint cluster region protein   [ EC ]
Protein also known as:  Renal carcinoma antigen NY-REN-26.
Gene name:  BCR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 352 2

Displayed isoform: Iso 1     



 show evidences
Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. The gene represented in this entry is involved in disease pathogenesis.  
  • CuratedUniProtKB
A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following diseases:
Chronic myeloid leukemia  521  
Distal 22q11.2 microdeletion syndrome  261330  
Precursor B-cell acute lymphoblastic leukemia  99860  
Precursor T-cell acute lymphoblastic leukemia  99861  


Proto-oncogene  definition   [KW-0656]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 613
MIM: 608232
PharmGKB: PA25321
Polymorphism databases
DMDM: 143811366
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.