ACADM - Medium-chain specific acyl-CoA dehydrogenase, mitochondrial - human protein (Function)
 
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ACADM »  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial   [ EC 1.3.8.7 ]  (MCAD)
 
Gene name:  ACADM
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This enzyme is specific for acyl chain lengths of 4 to 16.  
  • CuratedUniProtKB
GO molecular function 
Acyl-CoA dehydrogenase activitydefinition[GO:0003995]  
2
  • IDABHF-UCL
  • IMPUniProtKB
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Identical protein bindingdefinition[GO:0042802]  
1
  • IDABHF-UCL
Medium-chain-acyl-CoA dehydrogenase activitydefinition[GO:0070991]  
3
  • IDABHF-UCL
GO biological process 
Cardiac muscle cell differentiationdefinition[GO:0055007] silver  
  • IEAOrtholog Compara
Carnitine biosynthetic processdefinition[GO:0045329]  
1
  • IMPBHF-UCL
Carnitine metabolic process, CoA-linkeddefinition[GO:0019254]  
1
  • IMPBHF-UCL
Fatty acid beta-oxidationdefinition[GO:0006635]  
1
  • IMPUniProtKB
Fatty acid beta-oxidation using acyl-CoA dehydrogenasedefinition[GO:0033539]  
3
  • IDABHF-UCL
Glycogen biosynthetic processdefinition[GO:0005978] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Medium-chain fatty acid catabolic processdefinition[GO:0051793]  
1
  • IDABHF-UCL
Medium-chain fatty acid metabolic processdefinition[GO:0051791]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDABHF-UCL
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of gluconeogenesisdefinition[GO:0006111] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.8.7: A medium-chain acyl-CoA + electron-transfer flavoprotein a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+34  
Fatty acid metabolism  hsa00071+34  
Metabolic pathways  hsa01100+34  
PPAR signaling pathway  hsa03320+34  
Propanoate metabolism  hsa00640+34  
Valine, leucine and isoleucine degradation  hsa00280+34  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.  
  • CuratedUniProtKB
Utilizes the electron transfer flavoprotein (ETF) as electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P11310
Other
GenomeRNAi: 34
PRO: PR:P11310