FGFR1 - Fibroblast growth factor receptor 1 - human protein (Function)
 
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FGFR1 »  Fibroblast growth factor receptor 1   [ EC 2.7.10.1 ]  (FGFR-1)
 
Protein also known as:  Basic fibroblast growth factor receptor 1 (BFGFR); CD antigen CD331.
Gene name:  FGFR1
Entry whose protein(s) existence is based on evidence at protein level
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1 188 21
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.  
19
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Fibroblast growth factor bindingdefinition[GO:0017134]  
2
  • UniProtKB
Fibroblast growth factor-activated receptor activitydefinition[GO:0005007]  
3
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Protein bindingdefinition[GO:0005515]  
21
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Auditory receptor cell developmentdefinition[GO:0060117] silver  
1
  • Ortholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Chondrocyte differentiationdefinition[GO:0002062] silver  
1
  • Ortholog Compara
Chordate embryonic developmentdefinition[GO:0043009]  
1
  • UniProtKB
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
3
  • MGI
  • UniProtKB
Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentdefinition[GO:0035607] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Lung-associated mesenchyme developmentdefinition[GO:0060484] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • PINC
Mesenchymal cell differentiationdefinition[GO:0048762] silver  
1
  • Ortholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
1
  • Ortholog Compara
Middle ear morphogenesisdefinition[GO:0042474] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764]  
1
  • UniProtKB
Organ inductiondefinition[GO:0001759] silver  
1
  • Ortholog Compara
Outer ear morphogenesisdefinition[GO:0042473] silver  
1
  • Ortholog Compara
Paraxial mesoderm developmentdefinition[GO:0048339] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • UniProtKB
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
1
  • UniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
1
  • Ortholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
3
  • MGI
  • UniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
2
  • UniProtKB
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • UniProtKB
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwaydefinition[GO:0090080] silver  
1
  • Ortholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • UniProtKB
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • UniProtKB
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • UniProtKB
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • UniProtKB
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingdefinition[GO:0060665] silver  
1
  • Ortholog Compara
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • UniProtKB
Regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001239] silver  
1
  • Ortholog Compara
Regulation of lateral mesodermal cell fate specificationdefinition[GO:0048378] silver  
1
  • Ortholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
1
  • Ortholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Skeletal system morphogenesisdefinition[GO:0048705]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
Ventricular zone neuroblast divisiondefinition[GO:0021847] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
9
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues. Inhibited by ARQ 069; this compound maintains the kinase in an inactive conformation and inhibits autophosphorylation. Inhibited by PD173074.  
5
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+2260  
MAPK signaling pathway  hsa04010+2260  
Melanoma  hsa05218+2260  
Pathways in cancer  hsa05200+2260  
Prostate cancer  hsa05215+2260  
Regulation of actin cytoskeleton  hsa04810+2260  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1c and Klotho ligand binding and activation  REACT_9484  
FGFR1c ligand binding and activation  REACT_9515  
FRS2-mediated cascade  REACT_21247  
NCAM signaling for neurite out-growth  REACT_18334  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signal transduction by L1  REACT_22272  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR1 amplification mutants  REACT_120827  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fibroblast_growth_factor_receptor_1
GenomeRNAi: 2260
PRO: PR:P11362
Chemistry
GuidetoPHARMACOLOGY: 1808