FGFR1 - Fibroblast growth factor receptor 1 - human protein (Function)
 
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FGFR1 »  Fibroblast growth factor receptor 1   [ EC 2.7.10.1 ]  (FGFR-1)
 
Protein also known as:  Basic fibroblast growth factor receptor 1 (BFGFR); CD antigen CD331.
Gene name:  FGFR1
Entry whose protein(s) existence is based on evidence at protein level
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1 126 21
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.  
18
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Fibroblast growth factor bindingdefinition[GO:0017134]  
2
  • IDAUniProtKB
Fibroblast growth factor-activated receptor activitydefinition[GO:0005007]  
3
  • IDAUniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Auditory receptor cell developmentdefinition[GO:0060117] silver  
  • IEAOrtholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cell migrationdefinition[GO:0016477]  
1
  • TASUniProtKB
Chondrocyte differentiationdefinition[GO:0002062] silver  
  • IEAOrtholog Compara
Chordate embryonic developmentdefinition[GO:0043009]  
1
  • TASUniProtKB
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
3
  • IPIMGI
  • IDAUniProtKB
Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentdefinition[GO:0035607] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Lung-associated mesenchyme developmentdefinition[GO:0060484] silver  
  • IEAOrtholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • TASPINC
Mesenchymal cell differentiationdefinition[GO:0048762] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Middle ear morphogenesisdefinition[GO:0042474] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764]  
1
  • TASUniProtKB
Organ inductiondefinition[GO:0001759] silver  
  • IEAOrtholog Compara
Outer ear morphogenesisdefinition[GO:0042473] silver  
  • IEAOrtholog Compara
Paraxial mesoderm developmentdefinition[GO:0048339] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
1
  • TASUniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
3
  • IDAUniProtKB
  • IGIMGI
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
2
  • IDAUniProtKB
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IMPUniProtKB
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwaydefinition[GO:0090080] silver  
  • IEAOrtholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • IMPUniProtKB
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • TASUniProtKB
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • TASUniProtKB
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • NASUniProtKB
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingdefinition[GO:0060665] silver  
  • IEAOrtholog Compara
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • TASUniProtKB
Regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001239] silver  
  • IEAOrtholog Compara
Regulation of lateral mesodermal cell fate specificationdefinition[GO:0048378] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Skeletal system morphogenesisdefinition[GO:0048705]  
1
  • TASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Ventricular zone neuroblast divisiondefinition[GO:0021847] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
7
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues. Inhibited by ARQ 069; this compound maintains the kinase in an inactive conformation and inhibits autophosphorylation. Inhibited by PD173074.  
4
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+2260  
MAPK signaling pathway  hsa04010+2260  
Melanoma  hsa05218+2260  
Pathways in cancer  hsa05200+2260  
Prostate cancer  hsa05215+2260  
Regulation of actin cytoskeleton  hsa04810+2260  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fibroblast_growth_factor_receptor_1
GenomeRNAi: 2260
PRO: PR:P11362
Chemistry
GuidetoPHARMACOLOGY: 1808