ESRRA - Steroid hormone receptor ERR1 - human protein (Function)
 
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ESRRA »  Steroid hormone receptor ERR1
 
Protein also known as:  Nuclear receptor subfamily 3 group B member 1.
Gene name:  ESRRA
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 96 2
GENE REF ISO

Function

 show evidences
Overview 
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.  
5
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Steroid bindingdefinition[GO:0005496] silver  
  • IEAInterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • TASGOC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of osteoblast differentiationdefinition[GO:0045667] silver  
  • IEAOrtholog Compara
Regulation of osteoclast differentiationdefinition[GO:0045670] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Estrogen-related_receptor_alpha
GenomeRNAi: 2101
PRO: PR:P11474
Chemistry
GuidetoPHARMACOLOGY: 622