FGF3 - Fibroblast growth factor 3 - human protein (Function)
 
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FGF3 »  Fibroblast growth factor 3  (FGF-3)
 
Protein also known as:  Heparin-binding growth factor 3 (HBGF-3).
Gene name:  FGF3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.  
1
  • CuratedUniProtKB
GO molecular function 
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
  • IEAInterPro 2 GO
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
1
  • IGIMGI
Negative regulation of cardiac muscle tissue developmentdefinition[GO:0055026]  
1
  • IMPBHF-UCL
Organ inductiondefinition[GO:0001759] silver  
  • IEAOrtholog Compara
Otic vesicle formationdefinition[GO:0030916] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IGIMGI
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Semicircular canal morphogenesisdefinition[GO:0048752] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2248  
Melanoma  hsa05218+2248  
Pathways in cancer  hsa05200+2248  
Regulation of actin cytoskeleton  hsa04810+2248  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF3
GenomeRNAi: 2248
PRO: PR:P11487