CYP2A6 - Cytochrome P450 2A6 - human protein (Function)
 
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CYP2A6 »  Cytochrome P450 2A6   [ EC 1.14.13.- ]
 
Protein also known as:  1,4-cineole 2-exo-monooxygenase.
Gene name:  CYP2A6
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 152 1
GENE REF ISO

Function

 show evidences
Overview 
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.  
6
  • CuratedUniProtKB
GO molecular function 
Coumarin 7-hydroxylase activitydefinition[GO:0008389]  
3
  • IDABHF-UCL
  • IDAUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygendefinition[GO:0016712] silver  
  • IEAInterPro 2 GO
GO biological process 
Coumarin catabolic processdefinition[GO:0046226]  
1
  • IDABHF-UCL
Coumarin metabolic processdefinition[GO:0009804]  
1
  • IDABHF-UCL
Drug metabolic processdefinition[GO:0017144]  
2
  • IDABHF-UCL
Exogenous drug catabolic processdefinition[GO:0042738]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Steroid metabolic processdefinition[GO:0008202]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.-: 1,4-cineole + NADPH + O(2) 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Caffeine metabolism  hsa00232+1548  
Drug metabolism - cytochrome P450  hsa00982+1548  
Drug metabolism - other enzymes  hsa00983+1548  
Metabolic pathways  hsa01100+1548  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1548  
Retinol metabolism  hsa00830+1548  
According to Reactome, this protein belongs to the following pathways:
CYP2E1 reactions  REACT_13797  
Xenobiotics  REACT_13543  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 530 uM for 1,4-cineole
KM 0.23 uM for coumarin
Vmax 3.5 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P11509
Other
GeneWiki: CYP2A6
GenomeRNAi: 1548
PRO: PR:P11509