CETP - Cholesteryl ester transfer protein - human protein (Function)
 
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Gene
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CETP »  Cholesteryl ester transfer protein
 
Protein also known as:  Lipid transfer protein I.
Gene name:  CETP
Family name: BPI/LBP/Plunc » BPI/LBP
Entry whose protein(s) existence is based on evidence at protein level
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1 277 2
GENE REF ISO

Function

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Overview 
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed3600759, PubMed24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed17237796).  
4
  • UniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • BHF-UCL
Cholesterol transporter activitydefinition[GO:0017127]  
3
  • UniProtKB
  • BHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • BHF-UCL
Lipid transporter activitydefinition[GO:0005319]  
1
  • BHF-UCL
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • BHF-UCL
Phospholipid transporter activitydefinition[GO:0005548]  
1
  • BHF-UCL
Triglyceride bindingdefinition[GO:0017129]  
1
  • BHF-UCL
GO biological process 
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
2
  • BHF-UCL
Cholesterol transportdefinition[GO:0030301]  
2
  • UniProtKB
  • BHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
2
  • UniProtKB
  • BHF-UCL
Lipid homeostasisdefinition[GO:0055088]  
1
  • BHF-UCL
Lipid transportdefinition[GO:0006869]  
1
  • BHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • BHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • BHF-UCL
Phosphatidylcholine metabolic processdefinition[GO:0046470]  
1
  • BHF-UCL
Phospholipid homeostasisdefinition[GO:0055091]  
1
  • BHF-UCL
Phospholipid transportdefinition[GO:0015914]  
1
  • BHF-UCL
Regulation of cholesterol effluxdefinition[GO:0010874]  
1
  • BHF-UCL
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • BHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • BHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • BHF-UCL
Triglyceride transportdefinition[GO:0034197]  
1
  • UniProtKB
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
2
  • UniProtKB
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
HDL-mediated lipid transport  REACT_13621  
LDL-mediated lipid transport  REACT_6934  
Orphan transporters  REACT_268444  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links