SFTPC - Pulmonary surfactant-associated protein C - human protein (Function)
 
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SFTPC »  Pulmonary surfactant-associated protein C  (SP-C)
 
Protein also known as:  Pulmonary surfactant-associated proteolipid SPL(Val).
Gene name:  SFTPC
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Cellular response to nitric oxidedefinition[GO:0071732] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Respiratory gaseous exchangedefinition[GO:0007585]  
  • IEAUniProtKB KW
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to growth factordefinition[GO:0070848] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to interleukin-6definition[GO:0070741] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Note 
Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Gaseous exchange  definition   [KW-0305]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links