CYP2C9 - Cytochrome P450 2C9 - human protein (Function)
 
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CYP2C9 »  Cytochrome P450 2C9   [ EC 1.14.13.- ]
 
Protein also known as:  (S)-limonene 6-monooxygenase [EC 1.14.13.48].
Gene name:  CYP2C9
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 313 1
GENE REF ISO

Function

 show evidences
Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.  
  • CuratedUniProtKB
GO molecular function 
(R)-limonene 6-monooxygenase activitydefinition[GO:0052741]  
  • IEAEC 2 GO
(S)-limonene 6-monooxygenase activitydefinition[GO:0018675]  
  • IEAEC 2 GO
(S)-limonene 7-monooxygenase activitydefinition[GO:0018676]  
  • IEAEC 2 GO
Caffeine oxidase activitydefinition[GO:0034875]  
1
  • IDABHF-UCL
Drug bindingdefinition[GO:0008144]  
1
  • IDABHF-UCL
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
2
  • IDABHF-UCL
  • NASUniProtKB
Oxidoreductase activitydefinition[GO:0016491]  
2
  • IDABHF-UCL
Steroid hydroxylase activitydefinition[GO:0008395]  
1
  • IMPBHF-UCL
GO biological process 
Cellular amide metabolic processdefinition[GO:0043603]  
1
  • IDABHF-UCL
Drug catabolic processdefinition[GO:0042737]  
1
  • IMPBHF-UCL
Drug metabolic processdefinition[GO:0017144]  
3
  • IMPUniProtKB
  • IDABHF-UCL
Exogenous drug catabolic processdefinition[GO:0042738]  
1
  • IDABHF-UCL
Monocarboxylic acid metabolic processdefinition[GO:0032787]  
1
  • IDABHF-UCL
Monoterpenoid metabolic processdefinition[GO:0016098]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IDABHF-UCL
Oxidative demethylationdefinition[GO:0070989]  
1
  • IDABHF-UCL
Steroid metabolic processdefinition[GO:0008202]  
1
  • IMPBHF-UCL
Urea metabolic processdefinition[GO:0019627]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.14.13.80: (+)-(R)-limonene + NADPH + O(2) (+)-trans-carveol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
EC 1.14.13.48: (-)-(S)-limonene + NADPH + O(2) (-)-trans-carveol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
EC 1.14.13.49: (-)-(S)-limonene + NADPH + O(2) (-)-perillyl alcohol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+1559  
Drug metabolism - cytochrome P450  hsa00982+1559  
Linoleic acid metabolism  hsa00591+1559  
Metabolic pathways  hsa01100+1559  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1559  
Retinol metabolism  hsa00830+1559  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P11712
Other
GeneWiki: CYP2C9
GenomeRNAi: 1559
PRO: PR:P11712