ADH5 - Alcohol dehydrogenase class-3 - human protein (Function)
 
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ADH5 »  Alcohol dehydrogenase class-3   [ EC 1.1.1.1 ]
 
Protein also known as:  Glutathione-dependent formaldehyde dehydrogenase [EC 1.1.1.-] (FDH).
Gene name:  ADH5
Entry whose protein(s) existence is based on evidence at protein level
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1 41 1
GENE REF ISO

Function

 show evidences
Overview 
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.  
  • CuratedUniProtKB
GO molecular function 
Alcohol dehydrogenase (NAD) activitydefinition[GO:0004022]  
  • IEAEC 2 GO
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Fatty acid bindingdefinition[GO:0005504]  
1
  • IDAUniProtKB
Formaldehyde dehydrogenase activitydefinition[GO:0018467]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
S-(hydroxymethyl)glutathione dehydrogenase activitydefinition[GO:0051903]  
1
  • TASUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Ethanol catabolic processdefinition[GO:0006068] silver  
  • IEAOrtholog Compara
Ethanol oxidationdefinition[GO:0006069] silver  
  • IEAInterPro 2 GO
Formaldehyde catabolic processdefinition[GO:0046294] silver  
  • IEAOrtholog Compara
Peptidyl-cysteine S-nitrosylationdefinition[GO:0018119] silver  
  • IEAOrtholog Compara
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Respiratory system processdefinition[GO:0003016] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nitrosative stressdefinition[GO:0051409] silver  
  • IEAOrtholog Compara
Response to redox statedefinition[GO:0051775]  
1
  • IDAUniProtKB
Retinoid metabolic processdefinition[GO:0001523] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
An alcohol + NAD(+) an aldehyde or ketone + NADH.  
  • CuratedUniProtKB
EC 1.1.1.284: S-(hydroxymethyl)glutathione + NAD(P)(+) S-formylglutathione + NAD(P)H.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+128  
Fatty acid metabolism  hsa00071+128  
Glycolysis / Gluconeogenesis  hsa00010+128  
Metabolic pathways  hsa01100+128  
Metabolism of xenobiotics by cytochrome P450  hsa00980+128  
Retinol metabolism  hsa00830+128  
Tyrosine metabolism  hsa00350+128  
Note 
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P11766
Other
GeneWiki: ADH5
GenomeRNAi: 128
PRO: PR:P11766