CD79A - B-cell antigen receptor complex-associated protein alpha chain - human protein (Function)
 
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Protein
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References

 
CD79A »  B-cell antigen receptor complex-associated protein alpha chain
 
Protein also known as:  Membrane-bound immunoglobulin-associated protein; CD antigen CD79a.
Gene name:  CD79A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

 show evidences
Overview 
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.  
2
  • CuratedUniProtKB
GO molecular function 
Transmembrane signaling receptor activitydefinition[GO:0004888] silver  
  • IEAInterPro 2 GO
GO biological process 
B cell activationdefinition[GO:0042113]  
  • ISSOrtholog Curator
B cell differentiationdefinition[GO:0030183]  
  • ISSOrtholog Curator
B cell proliferationdefinition[GO:0042100]  
  • ISSOrtholog Curator
B cell receptor signaling pathwaydefinition[GO:0050853]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+973  
Primary immunodeficiency  hsa05340+973  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD79A
GenomeRNAi: 973
PRO: PR:P11912