ODC1 - Ornithine decarboxylase - human protein (Function)
 
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ODC1 »  Ornithine decarboxylase   [ EC 4.1.1.17 ]  (ODC)
 
Gene name:  ODC1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.  
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  • UniProtKB
GO molecular function 
Ornithine decarboxylase activitydefinition[GO:0004586]  
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  • UniProtKB
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
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  • Ortholog Curator
GO biological process 
Kidney developmentdefinition[GO:0001822] silver  
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  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
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  • Ortholog Compara
Putrescine biosynthetic process from ornithinedefinition[GO:0033387]  
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  • UniPathway
  • RefGenome
  • Ortholog Curator
Regulation of protein catabolic processdefinition[GO:0042176]  
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  • Ortholog Curator
Response to virusdefinition[GO:0009615]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.17: L-ornithine putrescine + CO(2).  
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  • UniProtKB
It requires the following cofactor
 pyridoxal 5'-phosphate  
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  • UniProtKB
It is regulated in the following manner
Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.  
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  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+4953  
Glutathione metabolism  hsa00480+4953  
Metabolic pathways  hsa01100+4953  
According to Reactome, this protein belongs to the following pathways:
Metabolism of polyamines  REACT_14820  
Regulation of ornithine decarboxylase (ODC)  REACT_13565  
 
More information is available from:
 

Keywords

Biological process 
Polyamine biosynthesis  definition   [KW-0620]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P11926
Other
GeneWiki: ODC1
GenomeRNAi: 4953
PRO: PR:P11926
Chemistry
GuidetoPHARMACOLOGY: 1276