NEFH - Neurofilament heavy polypeptide - human protein (Function)
 
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NEFH »  Neurofilament heavy polypeptide  (NF-H)
 
Protein also known as:  Neurofilament triplet H protein.
Gene name:  NEFH
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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1 33 2
GENE REF ISO

Function

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Overview 
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.  
  • CuratedUniProtKB
GO molecular function 
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Intermediate filament bundle assemblydefinition[GO:0045110] silver  
  • IEAOrtholog Compara
Microtubule cytoskeleton organizationdefinition[GO:0000226] silver  
  • IEAOrtholog Compara
Neurofilament cytoskeleton organizationdefinition[GO:0060052] silver  
  • IEAOrtholog Compara
Peripheral nervous system neuron axonogenesisdefinition[GO:0048936] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amyotrophic lateral sclerosis (ALS)  hsa05014+4744  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 4744
PRO: PR:P12036