F5 - Coagulation factor V - human protein (Function)
 
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F5 »  Coagulation factor V
 
Protein also known as:  Activated protein C cofactor. Cleaved into:  Coagulation factor V heavy chain; Coagulation factor V light chain.
Gene name:  F5
Family name: Multicopper oxidase
Entry whose protein(s) existence is based on evidence at protein level
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1 373 1
GENE REF ISO

Function

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Overview 
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.  
  • CuratedUniProtKB
GO molecular function 
Copper ion bindingdefinition[GO:0005507] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
GO biological process 
Blood circulationdefinition[GO:0008015] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
It is regulated in the following manner
Inhibited by SERPINA5.  
4
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2153  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Factor_V
GenomeRNAi: 2153
PRO: PR:P12259
Chemistry
GuidetoPHARMACOLOGY: 2606