CKB - Creatine kinase B-type - human protein (Function)
 
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CKB »  Creatine kinase B-type   [ EC 2.7.3.2 ]
 
Protein also known as:  Creatine kinase B chain.
Gene name:  CKB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. Creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Creatine kinase activitydefinition[GO:0004111]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Cellular chloride ion homeostasisdefinition[GO:0030644] silver  
  • IEAOrtholog Compara
Phosphorylationdefinition[GO:0016310]  
  • IEAUniProtKB KW
Substantia nigra developmentdefinition[GO:0021762]  
1
  • IEPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.3.2: ATP + creatine ADP + phosphocreatine.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+1152  
Metabolic pathways  hsa01100+1152  
According to Reactome, this protein belongs to the following pathway:
Creatine metabolism  REACT_813  
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P12277
Other
GeneWiki: CKB_(gene)
GenomeRNAi: 1152
PRO: PR:P12277