GZMA - Granzyme A - human protein (Function)
 
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GZMA »  Granzyme A   [ EC 3.4.21.78 ]
 
Protein also known as:  Cytotoxic T-lymphocyte proteinase 1.
Gene name:  GZMA
Family name: Peptidase S1 » Granzyme
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 2
GENE REF ISO

Function

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Overview 
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.  
4
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cytolysisdefinition[GO:0019835]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955]  
1
  • TASUniProtKB
Negative regulation of DNA bindingdefinition[GO:0043392]  
1
  • IDAUniProtKB
Negative regulation of endodeoxyribonuclease activitydefinition[GO:0032078]  
1
  • IDAUniProtKB
Negative regulation of oxidoreductase activitydefinition[GO:0051354]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.78: Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+3001  
Caution 
Exons 1a and 1b of the sequence reported in PubMed17180578 are of human origin, however exon 2 shows strong similarity to the rat sequence.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cytolysis  definition   [KW-0204]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GZMA
GenomeRNAi: 3001
PRO: PR:P12544