BMP2 - Bone morphogenetic protein 2 - human protein (Function)
 
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BMP2 »  Bone morphogenetic protein 2  (BMP-2)
 
Protein also known as:  Bone morphogenetic protein 2A (BMP-2A).
Gene name:  BMP2
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 341 1
GENE REF ISO

Function

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Overview 
Induces cartilage and bone formation.  
  • CuratedUniProtKB
GO molecular function 
BMP receptor bindingdefinition[GO:0070700]  
1
  • IDAMGI
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Phosphatase activator activitydefinition[GO:0019211]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIWormBase
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAMGI
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
Retinol dehydrogenase activitydefinition[GO:0004745]  
  • ISSOrtholog Curator
SMAD bindingdefinition[GO:0046332]  
1
  • IDABHF-UCL
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
2
  • IDADFLAT
  • IDAAgBase
Atrioventricular valve morphogenesisdefinition[GO:0003181]  
  • ISSOrtholog Curator
BMP signaling pathwaydefinition[GO:0030509]  
6
  • IDABHF-UCL
  • IMPMGI
  • IEPAgBase
BMP signaling pathway involved in heart inductiondefinition[GO:0003130]  
1
  • IDABHF-UCL
Bone mineralizationdefinition[GO:0030282]  
  • ISSOrtholog Curator
Bone mineralization involved in bone maturationdefinition[GO:0035630]  
1
  • IDABHF-UCL
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
  • ISSOrtholog Curator
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317]  
1
  • IDABHF-UCL
Cardiac muscle cell differentiationdefinition[GO:0055007]  
1
  • IMPBHF-UCL
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
  • ISSOrtholog Curator
Cardiocyte differentiationdefinition[GO:0035051]  
2
  • IMPBHF-UCL
  • IDAMGI
Cell fate commitmentdefinition[GO:0045165]  
  • ISSOrtholog Curator
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • IDABHF-UCL
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • IDAAgBase
Corticotropin hormone secreting cell differentiationdefinition[GO:0060128]  
  • ISSOrtholog Curator
Embryo developmentdefinition[GO:0009790]  
  • ISSOrtholog Curator
Embryonic heart tube anterior/posterior pattern specificationdefinition[GO:0035054]  
  • ISSOrtholog Curator
Endocardial cushion morphogenesisdefinition[GO:0003203]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
2
  • IDABHF-UCL
  • IDAMGI
Growthdefinition[GO:0040007] silver  
  • IEAInterPro 2 GO
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Inner ear developmentdefinition[GO:0048839]  
  • ISSOrtholog Curator
Mesenchymal cell differentiationdefinition[GO:0048762]  
1
  • IDAUniProtKB
Mesenchymal cell proliferation involved in ureteric bud developmentdefinition[GO:0072138]  
  • ISSOrtholog Curator
Mesenchyme developmentdefinition[GO:0060485]  
1
  • IMPBHF-UCL
Negative regulation of aldosterone biosynthetic processdefinition[GO:0032348]  
1
  • IDABHF-UCL
Negative regulation of calcium-independent cell-cell adhesiondefinition[GO:0051042]  
1
  • IDAAgBase
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IEPAgBase
Negative regulation of cardiac muscle cell differentiationdefinition[GO:2000726]  
1
  • IDABHF-UCL
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAHGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • IDABHF-UCL
  • IDAMGI
Negative regulation of cortisol biosynthetic processdefinition[GO:2000065]  
1
  • IDABHF-UCL
Negative regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043569]  
1
  • IDABHF-UCL
Negative regulation of steroid biosynthetic processdefinition[GO:0010894]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IDABHF-UCL
  • IDAMGI
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Negative regulation of Wnt signaling pathway involved in heart developmentdefinition[GO:0003308]  
1
  • IDABHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
  • ISSOrtholog Curator
Odontogenesis of dentin-containing toothdefinition[GO:0042475]  
  • ISSOrtholog Curator
Organ morphogenesisdefinition[GO:0009887]  
  • ISSOrtholog Curator
Osteoblast differentiationdefinition[GO:0001649]  
2
  • IDAMGI
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAOrtholog Compara
  • ISSOrtholog Curator
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
2
  • IDABHF-UCL
Pericardium developmentdefinition[GO:0060039]  
  • ISSOrtholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAMGI
Positive regulation of astrocyte differentiationdefinition[GO:0048711]  
  • ISSOrtholog Curator
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IDABHF-UCL
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • IDAMGI
Positive regulation of cell migrationdefinition[GO:0030335]  
  • ISSOrtholog Curator
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IDAUniProtKB
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
1
  • IDABHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • IDADFLAT
  • IMPBHF-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
  • ISSOrtholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IDAUniProtKB
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDADFLAT
Positive regulation of neuron differentiationdefinition[GO:0045666]  
  • ISSOrtholog Curator
Positive regulation of odontogenesisdefinition[GO:0042482]  
  • ISSOrtholog Curator
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • IDAMGI
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
3
  • IDABHF-UCL
Positive regulation of osteoblast proliferationdefinition[GO:0033690]  
  • ISSOrtholog Curator
Positive regulation of p38MAPK cascadedefinition[GO:1900745]  
1
  • IDADFLAT
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
4
  • IMPBHF-UCL
  • IMPUniProtKB
Positive regulation of phosphatase activitydefinition[GO:0010922]  
1
  • IDAMGI
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDAMGI
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • IDABHF-UCL
  • IDAMGI
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusdefinition[GO:1901522]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
  • ISSOrtholog Curator
Positive regulation of Wnt signaling pathway by BMP signaling pathwaydefinition[GO:0060804]  
  • ISSOrtholog Curator
Protein destabilizationdefinition[GO:0031648] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDADFLAT
Proteoglycan metabolic processdefinition[GO:0006029] silver  
  • IEAOrtholog Compara
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAHGNC
Response to hypoxiadefinition[GO:0001666]  
  • ISSOrtholog Curator
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • IDAUniProtKB
Telencephalon developmentdefinition[GO:0021537]  
1
  • IDAMGI
Telencephalon regionalizationdefinition[GO:0021978]  
  • ISSOrtholog Curator
Thyroid-stimulating hormone-secreting cell differentiationdefinition[GO:0060129]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+650  
Cytokine-cytokine receptor interaction  hsa04060+650  
Hedgehog signaling pathway  hsa04340+650  
Pathways in cancer  hsa05200+650  
TGF-beta signaling pathway  hsa04350+650  
According to Reactome, this protein belongs to the following pathways:
Molecules associated with elastic fibres  REACT_150331  
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links