BMP4 - Bone morphogenetic protein 4 - human protein (Function)
 
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BMP4 »  Bone morphogenetic protein 4  (BMP-4)
 
Protein also known as:  Bone morphogenetic protein 2B (BMP-2B).
Gene name:  BMP4
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 241 1
GENE REF ISO

Function

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Overview 
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).  
  • CuratedUniProtKB
GO molecular function 
BMP receptor bindingdefinition[GO:0070700]  
1
  • IDAMGI
Chemoattractant activitydefinition[GO:0042056]  
1
  • IDAUniProtKB
Cytokine activitydefinition[GO:0005125]  
1
  • IDAMGI
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIWormBase
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186]  
2
  • IDAUniProtKB
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
  • IEAOrtholog Compara
Blood vessel endothelial cell proliferation involved in sprouting angiogenesisdefinition[GO:0002043]  
1
  • IDABHF-UCL
BMP signaling pathwaydefinition[GO:0030509]  
3
  • IDABHF-UCL
  • IMPMGI
BMP signaling pathway involved in heart inductiondefinition[GO:0003130]  
1
  • IMPBHF-UCL
BMP signaling pathway involved in nephric duct formationdefinition[GO:0071893]  
1
  • IDAUniProtKB
BMP signaling pathway involved in renal system segmentationdefinition[GO:0061151]  
  • ISSOrtholog Curator
BMP signaling pathway involved in ureter morphogenesisdefinition[GO:0061149]  
  • ISSOrtholog Curator
Branching involved in prostate gland morphogenesisdefinition[GO:0060442] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • IDAUniProtKB
Branching morphogenesis of an epithelial tubedefinition[GO:0048754]  
1
  • IDAUniProtKB
Bronchus developmentdefinition[GO:0060433]  
1
  • IDAMGI
Bud dilation involved in lung branchingdefinition[GO:0060503]  
1
  • IDAMGI
Bud elongation involved in lung branchingdefinition[GO:0060449] silver  
  • IEAOrtholog Compara
Cardiac septum developmentdefinition[GO:0003279]  
1
  • TASBHF-UCL
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Chondrocyte differentiationdefinition[GO:0002062]  
  • ISSOrtholog Curator
Cloacal septationdefinition[GO:0060197] silver  
  • IEAOrtholog Compara
Common-partner SMAD protein phosphorylationdefinition[GO:0007182]  
1
  • IDAUniProtKB
Cranial suture morphogenesisdefinition[GO:0060363] silver  
  • IEAOrtholog Compara
Deltoid tuberosity developmentdefinition[GO:0035993]  
  • ISSOrtholog Curator
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
  • IEAOrtholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Embryonic skeletal joint morphogenesisdefinition[GO:0060272] silver  
  • IEAOrtholog Compara
Endocardial cushion developmentdefinition[GO:0003197]  
1
  • TASBHF-UCL
Endochondral ossificationdefinition[GO:0001958]  
  • ISSOrtholog Curator
Epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060502]  
1
  • IDAMGI
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441]  
1
  • IDAMGI
Epithelial-mesenchymal cell signalingdefinition[GO:0060684] silver  
  • IEAOrtholog Compara
Erythrocyte differentiationdefinition[GO:0030218] silver  
  • IEAOrtholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Glomerular capillary formationdefinition[GO:0072104]  
  • ISSOrtholog Curator
Glomerular visceral epithelial cell developmentdefinition[GO:0072015] silver  
  • IEAOrtholog Compara
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • IDAUniProtKB
Inner ear receptor cell differentiationdefinition[GO:0060113] silver  
  • IEAOrtholog Compara
Intermediate mesodermal cell differentiationdefinition[GO:0048392]  
1
  • IDAUniProtKB
Kidney developmentdefinition[GO:0001822]  
1
  • IMPUniProtKB
Lens induction in camera-type eyedefinition[GO:0060235] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286]  
1
  • IDAMGI
Lung morphogenesisdefinition[GO:0060425]  
1
  • IDAMGI
Lymphoid progenitor cell differentiationdefinition[GO:0002320]  
1
  • IMPBHF-UCL
Macrophage differentiationdefinition[GO:0030225]  
1
  • IDADFLAT
Mammary gland formationdefinition[GO:0060592] silver  
  • IEAOrtholog Compara
Mesenchymal cell differentiation involved in kidney developmentdefinition[GO:0072161] silver  
  • IEAOrtholog Compara
Mesenchymal cell proliferation involved in ureter developmentdefinition[GO:0072198] silver  
  • IEAOrtholog Compara
Mesenchymal cell proliferation involved in ureteric bud developmentdefinition[GO:0072138] silver  
  • IEAOrtholog Compara
Mesenchymal to epithelial transition involved in metanephros morphogenesisdefinition[GO:0003337]  
1
  • IDAUniProtKB
Mesodermal cell fate determinationdefinition[GO:0007500] silver  
  • IEAOrtholog Compara
Mesonephros developmentdefinition[GO:0001823]  
1
  • IEPUniProtKB
Metanephric collecting duct developmentdefinition[GO:0072205]  
  • ISSOrtholog Curator
Monocyte differentiationdefinition[GO:0030224]  
1
  • IDADFLAT
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathwaydefinition[GO:0072097]  
2
  • IDAUniProtKB
Negative regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090191]  
2
  • IDAUniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAHGNC
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAMGI
Negative regulation of cell proliferation involved in heart morphogenesisdefinition[GO:2000137]  
1
  • IMPBHF-UCL
Negative regulation of chondrocyte differentiationdefinition[GO:0032331] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of glomerular mesangial cell proliferationdefinition[GO:0072125]  
1
  • IDAUniProtKB
Negative regulation of glomerulus developmentdefinition[GO:0090194]  
1
  • IDAUniProtKB
Negative regulation of immature T cell proliferation in thymusdefinition[GO:0033088]  
1
  • IMPBHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IDAUniProtKB
Negative regulation of mesenchymal cell proliferation involved in ureter developmentdefinition[GO:0072200]  
1
  • IDAUniProtKB
Negative regulation of metanephric comma-shaped body morphogenesisdefinition[GO:2000007]  
1
  • IDAUniProtKB
Negative regulation of metanephric S-shaped body morphogenesisdefinition[GO:2000005]  
1
  • IDAUniProtKB
Negative regulation of mitosisdefinition[GO:0045839]  
1
  • IDAUniProtKB
Negative regulation of myoblast differentiationdefinition[GO:0045662]  
1
  • IDAMGI
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDAUniProtKB
Negative regulation of prostatic bud formationdefinition[GO:0060686] silver  
  • IEAOrtholog Compara
Negative regulation of striated muscle tissue developmentdefinition[GO:0045843]  
1
  • IDAMGI
Negative regulation of T cell differentiation in thymusdefinition[GO:0033085]  
1
  • IMPBHF-UCL
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAMGI
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
3
  • IDAUniProtKB
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Odontogenesisdefinition[GO:0042476]  
1
  • IGIUniProtKB
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IDABHF-UCL
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive chemotaxisdefinition[GO:0050918]  
1
  • IDAGOC
Positive regulation of apoptotic processdefinition[GO:0043065]  
2
  • IDAUniProtKB
  • IDAMGI
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
  • ISSOrtholog Curator
Positive regulation of bone mineralizationdefinition[GO:0030501]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of branching involved in lung morphogenesisdefinition[GO:0061047]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle fiber developmentdefinition[GO:0055020]  
1
  • IMPBHF-UCL
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • IDAMGI
Positive regulation of cell deathdefinition[GO:0010942]  
1
  • IDAMGI
Positive regulation of collagen biosynthetic processdefinition[GO:0032967]  
1
  • IDABHF-UCL
Positive regulation of DNA-dependent DNA replicationdefinition[GO:2000105]  
1
  • IDABHF-UCL
Positive regulation of endothelial cell differentiationdefinition[GO:0045603] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDAUniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IDAUniProtKB
Positive regulation of epidermal cell differentiationdefinition[GO:0045606]  
1
  • IDAUniProtKB
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IDABHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of kidney developmentdefinition[GO:0090184]  
1
  • IDAUniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • IDAMGI
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
5
  • IDABHF-UCL
  • IMPUniProtKB
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • IDAMGI
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDAMGI
Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
2
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IDAUniProtKB
Post-embryonic developmentdefinition[GO:0009791]  
1
  • IDAMGI
Protein localization to nucleusdefinition[GO:0034504]  
1
  • IDAUniProtKB
Pulmonary artery endothelial tube morphogenesisdefinition[GO:0061155]  
1
  • IDAUniProtKB
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
  • IEAOrtholog Compara
Regulation of cell fate commitmentdefinition[GO:0010453]  
1
  • IDAUniProtKB
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
  • IEAOrtholog Compara
Regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0060393]  
1
  • IDABHF-UCL
Regulation of smooth muscle cell differentiationdefinition[GO:0051150] silver  
  • IEAOrtholog Compara
Renal system developmentdefinition[GO:0072001]  
1
  • IEPUniProtKB
Renal system processdefinition[GO:0003014] silver  
  • IEAOrtholog Compara
Secondary heart field specificationdefinition[GO:0003139]  
1
  • IMPBHF-UCL
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • IDAUniProtKB
Smooth muscle tissue developmentdefinition[GO:0048745]  
  • ISSOrtholog Curator
Smoothened signaling pathwaydefinition[GO:0007224]  
1
  • IEPUniProtKB
Specification of organ positiondefinition[GO:0010159] silver  
  • IEAOrtholog Compara
Specification of ureteric bud anterior/posterior symmetry by BMP signaling pathwaydefinition[GO:0072101]  
2
  • IDAUniProtKB
Steroid hormone mediated signaling pathwaydefinition[GO:0043401]  
1
  • IMPUniProtKB
Telencephalon developmentdefinition[GO:0021537]  
1
  • IDAMGI
Telencephalon regionalizationdefinition[GO:0021978] silver  
  • IEAOrtholog Compara
Tendon cell differentiationdefinition[GO:0035990]  
  • ISSOrtholog Curator
Trachea developmentdefinition[GO:0060438]  
1
  • IDAMGI
Trachea formationdefinition[GO:0060440] silver  
  • IEAOrtholog Compara
Type B pancreatic cell developmentdefinition[GO:0003323]  
1
  • IDABHF-UCL
Ureter epithelial cell differentiationdefinition[GO:0072192]  
  • ISSOrtholog Curator
Ureter smooth muscle cell differentiationdefinition[GO:0072193]  
  • ISSOrtholog Curator
Ureteric bud developmentdefinition[GO:0001657]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+652  
Hedgehog signaling pathway  hsa04340+652  
Pathways in cancer  hsa05200+652  
TGF-beta signaling pathway  hsa04350+652  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links