SKI - Ski oncogene - human protein (Function)
 
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SKI »  Ski oncogene
 
Protein also known as:  Proto-oncogene c-Ski.
Gene name:  SKI
Family name: SKI
Entry whose protein(s) existence is based on evidence at protein level
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1 80 1
GENE REF ISO

Function

 show evidences
Overview 
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Histone deacetylase inhibitor activitydefinition[GO:0046811]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Repressing transcription factor bindingdefinition[GO:0070491]  
1
  • IPIUniProtKB
SMAD bindingdefinition[GO:0046332]  
2
  • IPIUniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
2
  • IDAUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Anterior/posterior axis specificationdefinition[GO:0009948]  
  • ISSOrtholog Curator
Bone morphogenesisdefinition[GO:0060349]  
  • ISSOrtholog Curator
Camera-type eye developmentdefinition[GO:0043010]  
  • ISSOrtholog Curator
Camera-type eye morphogenesisdefinition[GO:0048593]  
  • ISSOrtholog Curator
Cell motilitydefinition[GO:0048870]  
1
  • NASBHF-UCL
Cell proliferationdefinition[GO:0008283]  
1
  • NASBHF-UCL
Embryonic limb morphogenesisdefinition[GO:0030326]  
  • ISSOrtholog Curator
Face morphogenesisdefinition[GO:0060325]  
  • ISSOrtholog Curator
Lens morphogenesis in camera-type eyedefinition[GO:0002089]  
  • ISSOrtholog Curator
Myelination in peripheral nervous systemdefinition[GO:0022011]  
  • ISSOrtholog Curator
Myotube differentiationdefinition[GO:0014902]  
1
  • IDAUniProtKB
Negative regulation of activin receptor signaling pathwaydefinition[GO:0032926]  
1
  • IDAUniProtKB
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
2
  • IMPUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
  • ISSOrtholog Curator
Negative regulation of histone deacetylationdefinition[GO:0031064] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
1
  • IDAUniProtKB
Negative regulation of Schwann cell proliferationdefinition[GO:0010626]  
1
  • IGIMGI
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IDAUniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
4
  • IMPUniProtKB
  • IGIMGI
Neural tube closuredefinition[GO:0001843]  
  • ISSOrtholog Curator
Nose morphogenesisdefinition[GO:0043585]  
  • ISSOrtholog Curator
Olfactory bulb developmentdefinition[GO:0021772]  
  • ISSOrtholog Curator
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Positive regulation of DNA bindingdefinition[GO:0043388]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • NASBHF-UCL
Protein homotrimerizationdefinition[GO:0070207]  
1
  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
  • IBARefGenome
  • ISSOrtholog Curator
Retina development in camera-type eyedefinition[GO:0060041]  
  • ISSOrtholog Curator
Skeletal muscle fiber developmentdefinition[GO:0048741]  
  • ISSOrtholog Curator
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • IDAUniProtKB
Somatic stem cell maintenancedefinition[GO:0035019]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • ISSOrtholog Curator
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • NASBHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
Signaling by BMP  REACT_12034  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SKI_protein
GenomeRNAi: 6497
PRO: PR:P12755