ACTN1 - Alpha-actinin-1 - human protein (Function)
 
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ACTN1 »  Alpha-actinin-1
 
Protein also known as:  Alpha-actinin cytoskeletal isoform.
Gene name:  ACTN1
Family name: Alpha-actinin
Entry whose protein(s) existence is based on evidence at protein level
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1 96 4
GENE REF ISO

Function

 show evidences
Overview 
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • IDAMGI
Integrin bindingdefinition[GO:0005178]  
1
  • IDAUniProtKB
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Vinculin bindingdefinition[GO:0017166]  
1
  • IPIUniProtKB
GO biological process 
Actin crosslink formationdefinition[GO:0051764] silver  
  • IEAInterPro 2 GO
Actin filament bundle assemblydefinition[GO:0051017] silver  
  • IEAOrtholog Compara
Focal adhesion assemblydefinition[GO:0048041]  
1
  • IMPUniProtKB
Negative regulation of cellular component movementdefinition[GO:0051271]  
1
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+87  
Amoebiasis  hsa05146+87  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+87  
Focal adhesion  hsa04510+87  
Leukocyte transendothelial migration  hsa04670+87  
Regulation of actin cytoskeleton  hsa04810+87  
Systemic lupus erythematosus  hsa05322+87  
Tight junction  hsa04530+87  
According to Reactome, this protein belongs to the following pathways:
Nephrin interactions  REACT_23832  
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components  REACT_20580  
Syndecan interactions  REACT_163942  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Actinin,_alpha_1
GenomeRNAi: 87
PRO: PR:P12814