MYH7 - Myosin-7 - human protein (Function)
 
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MYH7 »  Myosin-7
 
Protein also known as:  Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).
Gene name:  MYH7
Entry whose protein(s) existence is based on evidence at protein level
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1 166 1
GENE REF ISO

Function

 show evidences
Overview 
Muscle contraction.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Actin-dependent ATPase activitydefinition[GO:0030898]  
1
  • IMPHGNC
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • IDAHGNC
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Microfilament motor activitydefinition[GO:0000146]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Structural constituent of muscledefinition[GO:0008307]  
2
  • IDAHGNC
GO biological process 
Adult heart developmentdefinition[GO:0007512]  
1
  • IMPHGNC
ATP catabolic processdefinition[GO:0006200]  
1
  • IDABHF-UCL
Muscle contractiondefinition[GO:0006936]  
2
  • TASHGNC
Muscle filament slidingdefinition[GO:0030049]  
2
  • IMPHGNC
Regulation of heart ratedefinition[GO:0002027]  
1
  • IDAHGNC
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
2
  • IMPBHF-UCL
  • IMPHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+4625  
Dilated cardiomyopathy  hsa05414+4625  
Hypertrophic cardiomyopathy (HCM)  hsa05410+4625  
Tight junction  hsa04530+4625  
Viral myocarditis  hsa05416+4625  
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
Note 
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.  
  • CuratedUniProtKB
Caution 
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Motor protein  definition   [KW-0505]
Muscle protein  definition   [KW-0514]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYH7
GenomeRNAi: 4625
PRO: PR:P12883